{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T17:44:16Z","timestamp":1760204656565,"version":"3.40.4"},"reference-count":31,"publisher":"S. Karger AG","issue":"3-4","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>Pulmonary arterial hypertension (PAH) still cannot be cured effectively, hence the search for novel treatments continues. The effects of sildenafil (25 mg\/kg body weight) and fasudil (30 mg\/kg body weight) given alone or in combination, on normalization of right ventricular pressure (RVP), right ventricle mass, as well as the levels of several biomarkers (HDL-C, BNP, VEGF-A), were assessed in a rat model of monocrotaline (MCT)-induced PAH. MCT (60 mg\/kg body weight) induced clear PAH in male Wistar rats. After 21 days, a significant decrease in RVP accompanied by a reduction of right ventricular hypertrophy - a significant decrease in the right ventricle\/left ventricle plus septum ratio - as a result of sildenafil or fasudil administration was assessed. The administration of fasudil and sildenafil alone or in combination caused a significant decrease in plasma BNP level as compared to MCT-treated rats. Fasudil alone or with sildenafil, but not sildenafil alone, significantly increased HDL-C level as compared to MCT-treated rats. Fasudil and sildenafil given alone or in combination caused a significant increase in plasma VEGF-A level as compared to rats exposed to MCT.<\/jats:p>","DOI":"10.1159\/000346921","type":"journal-article","created":{"date-parts":[[2013,2,21]],"date-time":"2013-02-21T09:28:43Z","timestamp":1361438923000},"page":"178-184","source":"Crossref","is-referenced-by-count":10,"title":["The Beneficial Impact of Fasudil and Sildenafil on Monocrotaline-Induced Pulmonary Hypertension in Rats: A Hemodynamic and Biochemical Study"],"prefix":"10.1159","volume":"91","author":[{"given":"Magdalena","family":"Jasi\u0144ska-Stroschein","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacek","family":"Owczarek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"\u0141ucza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daria","family":"Orszulak-Michalak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2013,2,21]]},"reference":[{"doi-asserted-by":"publisher","key":"ref1","DOI":"10.1056\/NEJMra035488"},{"doi-asserted-by":"publisher","key":"ref2","DOI":"10.1016\/j.jacc.2009.04.018"},{"doi-asserted-by":"publisher","key":"ref3","DOI":"10.1016\/S0735-1097(02)02012-0"},{"doi-asserted-by":"publisher","key":"ref4","DOI":"10.1056\/NEJMoa012212"},{"doi-asserted-by":"publisher","key":"ref5","DOI":"10.1164\/rccm.200307-957OC"},{"doi-asserted-by":"publisher","key":"ref6","DOI":"10.1056\/NEJMoa050010"},{"doi-asserted-by":"publisher","key":"ref7","DOI":"10.1093\/eurheartj\/ehp297"},{"doi-asserted-by":"publisher","key":"ref8","DOI":"10.1378\/chest.07-2111"},{"doi-asserted-by":"publisher","key":"ref9","DOI":"10.1097\/FJC.0b013e31806befe6"},{"doi-asserted-by":"publisher","key":"ref10","DOI":"10.1183\/09031936.00081706"},{"doi-asserted-by":"publisher","key":"ref11","DOI":"10.1164\/rccm.200603-358OC"},{"doi-asserted-by":"publisher","key":"ref12","DOI":"10.1016\/j.amjcard.2005.06.083"},{"doi-asserted-by":"publisher","key":"ref13","DOI":"10.1111\/j.1742-1241.2010.02598.x"},{"doi-asserted-by":"publisher","key":"ref14","DOI":"10.1038\/sj.bjp.0706408"},{"doi-asserted-by":"publisher","key":"ref15","DOI":"10.1590\/S0100-879X2008000800003"},{"doi-asserted-by":"publisher","key":"ref16","DOI":"10.4070\/kcj.2010.40.12.659"},{"doi-asserted-by":"publisher","key":"ref17","DOI":"10.1161\/01.RES.0000126050.41296.8E"},{"doi-asserted-by":"publisher","key":"ref18","DOI":"10.1016\/j.ejphar.2011.05.060"},{"doi-asserted-by":"publisher","key":"ref19","DOI":"10.3109\/10408449209146311"},{"doi-asserted-by":"publisher","key":"ref20","DOI":"10.1152\/ajplung.00212.2011"},{"doi-asserted-by":"publisher","key":"ref21","DOI":"10.1097\/FJC.0b013e31802df112"},{"doi-asserted-by":"publisher","key":"ref22","DOI":"10.1016\/j.amjcard.2011.07.025"},{"doi-asserted-by":"publisher","key":"ref23","DOI":"10.1517\/14728222.2010.523421"},{"doi-asserted-by":"publisher","key":"ref24","DOI":"10.1291\/hypres.29.123"},{"doi-asserted-by":"publisher","key":"ref25","DOI":"10.1291\/hypres.27.625"},{"doi-asserted-by":"publisher","key":"ref26","DOI":"10.1291\/hypres.26.971"},{"doi-asserted-by":"publisher","key":"ref27","DOI":"10.1161\/01.CIR.0000143836.40431.F5"},{"doi-asserted-by":"publisher","key":"ref28","DOI":"10.1172\/JCI117858"},{"doi-asserted-by":"publisher","key":"ref29","DOI":"10.3109\/10641963.2011.631652"},{"doi-asserted-by":"publisher","key":"ref30","DOI":"10.1016\/j.amjcard.2012.03.042"},{"doi-asserted-by":"publisher","key":"ref31","DOI":"10.1164\/rccm.201001-0007OC"}],"container-title":["Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/346921","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/346921","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:51:23Z","timestamp":1745434283000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000346921"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":31,"journal-issue":{"issue":"3-4","published-online":{"date-parts":[[2013,5,1]]},"published-print":{"date-parts":[[2013,5,13]]}},"URL":"https:\/\/doi.org\/10.1159\/000346921","archive":["Portico"],"relation":{},"ISSN":["0031-7012","1423-0313"],"issn-type":[{"type":"print","value":"0031-7012"},{"type":"electronic","value":"1423-0313"}],"subject":[],"published":{"date-parts":[[2013]]}}}