{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:27:39Z","timestamp":1761895659850,"version":"3.40.4"},"reference-count":33,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2013,4,16]],"date-time":"2013-04-16T00:00:00Z","timestamp":1366070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,4,16]],"date-time":"2013-04-16T00:00:00Z","timestamp":1366070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; The diagnostic evaluation of patients presenting with possible lung cancer is often complex and time consuming. A rapid outpatient diagnostic program (RODP) including &lt;sup&gt;18&lt;\/sup&gt;F-fluorodeoxyglucose positron emission tomography (FDG-PET) and contrast-enhanced computed tomography (CT) as a routine diagnostic tool may improve timeliness, however the diagnostic performance of such a combined approach of RODP remains unclear. &lt;b&gt;&lt;i&gt;Objectives:&lt;\/i&gt;&lt;\/b&gt; We evaluated timeliness of care and diagnostic performance of FDG-PET and contrast-enhanced CT (FDG-PET\/CT) in an RODP for all patients referred with a chest X-ray suspicious of lung cancer. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Charts of patients referred to the 2-day RODP of our tertiary care university clinic after an abnormal chest X-ray between 1999 and 2009 were reviewed. Between 1999 and 2005 co-registered FDG-PET and CT imaging took place; from September 2005 onwards, a hybrid system was used. We analyzed timeliness of care and diagnostic performance of FDG-PET\/CT to differentiate malignant from benign lesions. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; In 386 patients available for analysis, 260 were diagnosed with lung cancer and 23 had another type of malignancy; in 78 patients benign disease was confirmed, and in another 45 the diagnosis was not pathologically confirmed but a median 24.5-month follow-up confirmed a benign outcome. Sensitivity, specificity, negative and positive predictive values and accuracy of FDG-PET\/CT to differentiate lung cancer from benign disease were 97.7, 60.2, 92.5, 84.0 and 85.8%, respectively. Lung cancer patients had a median referral, diagnostic and therapeutic delay of 7, 2 and 19 days, respectively. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; FDG-PET\/CT in an RODP setting for suspected lung cancer has high performance in detecting cancer and facilitates timely care.<\/jats:p>","DOI":"10.1159\/000347096","type":"journal-article","created":{"date-parts":[[2013,4,16]],"date-time":"2013-04-16T08:17:02Z","timestamp":1366100222000},"page":"32-37","source":"Crossref","is-referenced-by-count":8,"title":["High Performance of &lt;sup&gt;18&lt;\/sup&gt;F-Fluorodeoxyglucose Positron Emission Tomography and Contrast-Enhanced CT in a Rapid Outpatient Diagnostic Program for Patients with Suspected Lung Cancer"],"prefix":"10.1159","volume":"87","author":[{"given":"Pepijn","family":"Brocken","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henricus F.M.","family":"van der Heijden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.N. Richard","family":"Dekhuijzen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liesbeth","family":"Peters-Bax","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lioe-Fee","family":"de Geus-Oei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2013,4,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20073"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602798"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2006.01237.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3816\/CLC.2006.n.005"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097\/01243894-200609000-00015"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejon.2004.08.001"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1136\/thx.53.6.445"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-5002(03)00358-1"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2008.109330"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9776(98)90073-X"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.324.7336.507"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/pon.1929"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00035108"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2008.09.006"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022136"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2292021598"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e3181b2b782"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1378\/chest.111.6.1710"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1053\/clon.2000.9139"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1186\/1749-8090-2-5"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-5002(01)00293-8"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.4.2282"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.3109\/2000-1967-236"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e318158d4b6"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1159\/000078318"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1998.690"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.7.914"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(01)01477-8"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2003.07.030"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-16201"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2302021685"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.109.072090"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0900043"}],"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/347096","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/347096","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:52:37Z","timestamp":1745434357000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000347096"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,16]]},"references-count":33,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2014,1,1]]},"published-print":{"date-parts":[[2014,1,24]]}},"URL":"https:\/\/doi.org\/10.1159\/000347096","archive":["Portico"],"relation":{},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"type":"print","value":"0025-7931"},{"type":"electronic","value":"1423-0356"}],"subject":[],"published":{"date-parts":[[2013,4,16]]}}}