{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T09:44:13Z","timestamp":1768815853197,"version":"3.49.0"},"reference-count":30,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>Immunodeficiency due to anti-interferon-gamma autoantibody (anti-IFN-&amp;#947; autoAb) is an emerging adult-onset immunodeficiency syndrome predominantly found in Southeast Asians. It is associated with severe or disseminated infections caused by non-tuberculous mycobacteria (NTM) and other opportunistic pathogens. We describe 3 patients with anti-IFN-&amp;#947; autoAb who developed reactive and infective dermatoses, and thoroughly review the existing literature on dermatoses associated with the immunodeficiency syndrome. Case 1 developed Sweet's syndrome associated with &lt;i&gt;Mycobacterium chelonae&lt;\/i&gt; lymphadenitis and penicilliosis. Case 2 suffered from multiple episodes of lobular panniculitis during recurrent infections by NTM, &lt;i&gt;Penicillium marneffei&lt;\/i&gt; and &lt;i&gt;Burkholderia pseudomallei&lt;\/i&gt;. Both cases responded to immunomodulating agents including corticosteroid and non-steroidal anti-inflammatory drugs. Case 3 had direct skin invasion by &lt;i&gt;M. chelonae&lt;\/i&gt; and responded to prolonged anti-mycobacterial therapy. A novel working algorithm is proposed for the diagnosis and treatment of these patients who may be encountered by the dermatologist and histopathologist in clinical practice.<\/jats:p>","DOI":"10.1159\/000347112","type":"journal-article","created":{"date-parts":[[2013,5,6]],"date-time":"2013-05-06T10:12:33Z","timestamp":1367835153000},"page":"157-166","source":"Crossref","is-referenced-by-count":55,"title":["Reactive and Infective Dermatoses Associated with Adult-Onset Immunodeficiency due to Anti-Interferon-Gamma Autoantibody: Sweet's Syndrome and Beyond"],"prefix":"10.1159","volume":"226","author":[{"given":"Jasper Fuk-Woo","family":"Chan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nigel Jeremy","family":"Trendell-Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johnny 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