{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T02:42:12Z","timestamp":1772764932544,"version":"3.50.1"},"reference-count":21,"publisher":"S. Karger AG","issue":"3-4","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background\/Aims:&lt;\/i&gt;&lt;\/b&gt; The natural history of Alzheimer's disease (AD) has rarely been studied in the Korean population. Our study on survival analyses in Korean AD patients potentially provides a basis for cross-cultural comparisons. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; We studied 724 consecutive patients from a memory disorder clinic in a tertiary hospital in Seoul, who were diagnosed as having AD between April 1995 and December 2005. Deaths were identified by the Statistics Korea database. The Kaplan-Meier method was used for survival analysis, and a Cox proportional hazard model was used to assess factors related to patient survival. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; The overall median survival from the onset of first symptoms and from the time of diagnosis was 12.6 years (95% confidence interval 11.7-13.4) and 9.3 years (95% confidence interval 8.7-9.9), respectively. The age of onset, male gender, history of diabetes mellitus, lower Mini-Mental State Examination score, and higher Clinical Dementia Rating score were negatively associated with survival. There was a reversal of risk of AD between early-onset and later-onset AD, 9.1 years after onset. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; The results of our study show a different pattern of survival compared to those studies carried out with western AD populations. Mortality risk of early-onset AD varied depending on the duration of follow-up.<\/jats:p>","DOI":"10.1159\/000347133","type":"journal-article","created":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T20:11:14Z","timestamp":1362168674000},"page":"219-228","source":"Crossref","is-referenced-by-count":29,"title":["Survival of Alzheimer's Disease Patients in Korea"],"prefix":"10.1159","volume":"35","author":[{"given":"Seok Min","family":"Go","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kang Soo","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Won","family":"Seo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juhee","family":"Chin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sue J.","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"So Young","family":"Moon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duk L.","family":"Na","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hae-Kwan","family":"Cheong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2013,3,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1371%2Fjournal.pmed.0030442"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001%2Farchinte.151.5.989"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1212%2FWNL.44.10.1869"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneur.59.11.1764"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneur.62.5.779"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1212%2FWNL.46.3.656"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM200104123441501"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1212%2F01.wnl.0000285287.99923.3c"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1212%2F01.wnl.0000334278.11022.42"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159%2F000087300"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1212%2FWNL.50.2.362"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1136%2Fjnnp.2008.155481"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1212%2FWNL.34.7.939"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1093%2Faje%2F154.7.642"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159%2F000048643"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1159%2F000086680"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1159%2F000149585"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1186%2Falzrt119"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.410370508"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1017%2FS0033291799008867"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1212%2FWNL.49.3.798"}],"container-title":["Dementia and Geriatric Cognitive Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/347133","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/347133","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:53:01Z","timestamp":1745434381000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000347133"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":21,"journal-issue":{"issue":"3-4","published-online":{"date-parts":[[2013,3,1]]},"published-print":{"date-parts":[[2013,3,21]]}},"URL":"https:\/\/doi.org\/10.1159\/000347133","archive":["Portico"],"relation":{},"ISSN":["1420-8008","1421-9824"],"issn-type":[{"value":"1420-8008","type":"print"},{"value":"1421-9824","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}