{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:35:41Z","timestamp":1745469341282,"version":"3.40.4"},"reference-count":9,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Precursor B-cell acute lymphocytic leukemia (ALL) with surface immunoglobulin light chain expression is a rare disease entity. The differential diagnosis is difficult but critical for disease management. &lt;b&gt;&lt;i&gt;Aims&lt;\/i&gt;&lt;\/b&gt;: We report 2 cases (1 adult and 1 infant) of precursor B-cell ALL who presented at diagnosis with surface immunoglobulin light chain expression revealed by flow cytometric immunophenotyping and discuss its clinical significance. &lt;b&gt;&lt;i&gt;Case Report:&lt;\/i&gt;&lt;\/b&gt; The 2 patients presented with nonspecific symptoms such as fever, pallor, fatigue or lymphadenopathy. Flow cytometric immunophenotyping showed that both patients expressed CD34\/CD19\/CD10\/CD22\/CD9\/HLA-DR\/CD38\/CD123\/CD13 (partial) and had unexpected single &amp;#x03BB; light chain expression. Cytogenetic analysis revealed t(9;22)(q34;q11) in the adult patient and normal karyotype in the infant. Both cases were diagnosed and managed as precursor B-ALL, and the patients showed good response to treatment regimens. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; We describe 2 cases of precursor B-ALL with unexpected surface light chain expression. The exceedingly rare immunophenotypes have diagnostic implication for immunophenotyping of this malignancy. Treatment regimens for precursor B-cell ALL are suitable for such cases.<\/jats:p>","DOI":"10.1159\/000347165","type":"journal-article","created":{"date-parts":[[2013,6,11]],"date-time":"2013-06-11T07:42:22Z","timestamp":1370936542000},"page":"188-191","source":"Crossref","is-referenced-by-count":2,"title":["Precursor B-Cell Lymphoblastic Leukemia with Surface Immunoglobulin Light Chain Expression in 2 Chinese Patients"],"prefix":"10.1159","volume":"130","author":[{"given":"Yanhui","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaping","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yulong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2013,6,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.4065%2F80.11.1517"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.semdp.2011.02.008"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.hoc.2009.04.006"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2559.2010.03703.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2141.1988.tb04229.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1309%2FWTXCQ5NRACVXTYBY"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS0145-2126%2802%2900129-7"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097%2F01.mph.0000142493.56793.cb"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159%2F000203798"}],"container-title":["Acta Haematologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/347165","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/347165","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/347165","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:53:24Z","timestamp":1745434404000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000347165"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":9,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2013,9,1]]},"published-print":{"date-parts":[[2013,9,25]]}},"URL":"https:\/\/doi.org\/10.1159\/000347165","archive":["Portico"],"relation":{},"ISSN":["0001-5792","1421-9662"],"issn-type":[{"type":"print","value":"0001-5792"},{"type":"electronic","value":"1421-9662"}],"subject":[],"published":{"date-parts":[[2013]]}}}