{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T04:42:31Z","timestamp":1762144951118,"version":"3.40.4"},"reference-count":23,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Introduction:&lt;\/i&gt;&lt;\/b&gt; Renal ischemia-reperfusion (I\/R) injury is a primary cause of acute renal failure that results in high mortality. This study aimed to investigate the effect of osthole, a natural coumarin derivative, on renal I\/R injury in a rat model. &lt;b&gt;&lt;i&gt;Materials and Methods:&lt;\/i&gt;&lt;\/b&gt; Rats were randomly allocated to the sham operation + vehicle, I\/R + vehicle, and I\/R + osthole groups. Renal I\/R injury was induced by clamping the left renal artery for 45 min followed by 12 h of reperfusion and a contralateral nephrectomy. Osthole (40 mg\/kg) was intraperitoneally injected 30 min before inducing I\/R. Renal function and histological damage were determined subsequently. Myeloperoxidase activity, monocyte\/macrophage infiltration, as well as tumor necrosis factor-\u03b1, IL-1\u03b2, and activated p38 mitogen-activated protein kinase expression in kidneys were also assessed. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Osthole treatment significantly ameliorated I\/R-induced renal functional and morphological injuries. Moreover, osthole treatment attenuated myeloperoxidase activity, monocyte\/macrophage infiltration, and tumor necrosis factor-\u03b1, IL-1\u03b2, and activated p38 mitogen-activated protein kinase expression in kidneys. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Osthole treatment ameliorates renal I\/R injury by inhibiting inflammatory responses in kidneys. Thus, osthole may represent a novel practical strategy to prevent renal I\/R injury.<\/jats:p>","DOI":"10.1159\/000347191","type":"journal-article","created":{"date-parts":[[2013,3,25]],"date-time":"2013-03-25T07:58:21Z","timestamp":1364198301000},"page":"350-356","source":"Crossref","is-referenced-by-count":14,"title":["Osthole Ameliorates Renal Ischemia-Reperfusion Injury by Inhibiting Inflammatory Response"],"prefix":"10.1159","volume":"91","author":[{"given":"Yi","family":"Zheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lulin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shudong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2013,3,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17406-0"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2005.00826.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119457"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(02)01606-4"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S1875-9572(08)60028-5"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.09.052"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.1998.00851.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/15.10.1562"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2008070712"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2004090802"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2010.06.055"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e318160f0d1"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181d8e9dc"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199710150-00001"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199605303342207"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.00726.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfk047"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1172\/JCI15606"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1999.00644.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2008.01.011"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1097\/00005392-199907000-00068"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/17.3.399"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1021\/jf102812t"}],"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/347191","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/347191","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:53:50Z","timestamp":1745434430000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000347191"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":23,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2013,10,1]]},"published-print":{"date-parts":[[2013,10,14]]}},"URL":"https:\/\/doi.org\/10.1159\/000347191","archive":["Portico"],"relation":{},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"type":"print","value":"0042-1138"},{"type":"electronic","value":"1423-0399"}],"subject":[],"published":{"date-parts":[[2013]]}}}