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PSC patients have an increased risk to develop hepatobiliary as well as extrahepatic malignancies. The goal of a surveillance strategy for hepatobiliary malignancy in these patients is the detection of early cancer which will allow a potentially curative therapy. Here, we focus on a conceptual review of the pathogenesis of cholangiocellular carcinoma and gallbladder cancer and we will discuss a rational approach for the surveillance of these malignancies in PSC patients.<\/jats:p>","DOI":"10.1159\/000347206","type":"journal-article","created":{"date-parts":[[2013,6,18]],"date-time":"2013-06-18T08:30:33Z","timestamp":1371544233000},"page":"118-125","source":"Crossref","is-referenced-by-count":21,"title":["Primary Sclerosing Cholangitis and Cholangiocarcinoma: Pathogenesis and Modes of 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