{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T11:47:19Z","timestamp":1789386439132,"version":"build-2803163510"},"reference-count":22,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Stereotact Funct Neurosurg"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; For 30% of anorexia nervosa (AN) patients, conventional treatments are unsuccessful; this is termed intractable AN. &lt;b&gt;&lt;i&gt;Objectives:&lt;\/i&gt;&lt;\/b&gt; This study investigates whether ablation of the nucleus accumbens (NAc) using stereotactic surgery can arouse the physiological drive to eat in intractable AN patients. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Eight patients with intractable AN were included: 6 patients underwent bilateral stereotactic radio frequency ablation in the NAc and 2 patients received bilateral NAc deep brain stimulation (DBS). Observations were made for basic vital signs, body mass index (BMI), menstruation, depression, anxiety, obsessive-compulsive disorder, personality, intelligence, memory, quality of life, social functioning, as well as complications and adverse events associated with the treatment. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Basic vital signs, BMI and menstruation had recovered 1 year after the operation. Depression, anxiety and obsessive-compulsive disorder were improved 1 year postoperatively. There were changes in personality scores for psychoticism, neuroticism and lie tendencies that seemed to be helpful to the recovery from AN. Intelligence and memory improved after 6 months postoperatively. Quality of life and social functioning were dramatically improved at 1 year postoperatively. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; The results of this study reveal that ablation of the NAc can increase the AN patients' physiological drive to eat. Furthermore, there were no severe and\/or life-influencing complications associated with the treatment.<\/jats:p>","DOI":"10.1159\/000348278","type":"journal-article","created":{"date-parts":[[2013,10,15]],"date-time":"2013-10-15T07:48:24Z","timestamp":1381823304000},"page":"364-372","source":"Crossref","is-referenced-by-count":47,"title":["Treatment of Intractable Anorexia Nervosa with Inactivation of the Nucleus Accumbens Using Stereotactic Surgery"],"prefix":"10.1159","volume":"91","author":[{"given":"Jing","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chongwang","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuelian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guodong","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2013,10,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002%2Ferv.805"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2803%2912378-1"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1177%2F0884533609357566"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1192%2Fbjp.bp.110.083881"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ejim.2010.12.010"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1080%2F10640266.2011.551635"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1186%2F1751-0759-6-4"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2809%2961748-7"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1001%2Farchinte.165.5.561"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1192%2Fbjp.bp.108.054742"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1176%2Fappi.ajp.159.8.1284"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291098-108X%28199704%2921%3A3%3C205%3A%3AAID-EAT1%3E3.0.CO%3B2-O"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2FS0193-953X%2805%2970385-3"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002%2Feat.20367"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2899%2905363-5"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.7326%2F0003-4819-36-2-647"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291098-108X%28200004%2927%3A3%3C249%3A%3AAID-EAT1%3E3.0.CO%3B2-K"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jpsychires.2010.07.012"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.0701471104"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1176%2Fappi.ajp.2009.09010071"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1159%2F000075111"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1038%2Faps.2012.10"}],"container-title":["Stereotactic and Functional Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/348278","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/348278","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:54:53Z","timestamp":1745434493000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000348278"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":22,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2013,11,1]]},"published-print":{"date-parts":[[2013,11,13]]}},"URL":"https:\/\/doi.org\/10.1159\/000348278","archive":["Portico"],"relation":{},"ISSN":["1011-6125","1423-0372"],"issn-type":[{"value":"1011-6125","type":"print"},{"value":"1423-0372","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}