{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T17:47:39Z","timestamp":1759600059363,"version":"3.40.4"},"reference-count":25,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiology"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objectives: &lt;\/i&gt;&lt;\/b&gt;To investigate ghrelin levels in patients with idiopathic pulmonary arterial hypertension (IPAH) and the association of ghrelin with N-terminal brain natriuretic peptide (N-BNP), endothelin-1 (ET-1) and nitric oxide (NO). &lt;b&gt;&lt;i&gt;Methods: &lt;\/i&gt;&lt;\/b&gt;Plasma ghrelin, N-BNP, ET-1 and NO were measured, and echocardiography was performed in 20 IPAH patients and in 20 control subjects matched for age, sex and body mass index. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Plasma ghrelin and NT-proBNP levels were significantly higher in IPAH patients compared with values in control subjects (p &lt; 0.05). In IPAH patients, ghrelin levels correlated positively with N-BNP (r = 0.616, p = 0.004), NO (r = 0.464, p = 0.039), right ventricle diameter (RVD; r = 0.485, p = 0.030) and pulmonary arterial systolic pressure (PASP; r = 0.591, p = 0.006). N-BNP levels correlated positively with RVD (r = 0.551, p = 0.012) and ET-1 (r = 0.451, p = 0.046). &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Plasma ghrelin levels were elevated in IPAH. Increased ghrelin levels correlated positively with N-BNP, PASP, RVD and NO, and N-BNP levels correlated positively with RVD and ET-1. Pulmonary vascular pathology is a complex imbalance of opposing forces. Ghrelin may not only provide a novel prognostic biomarker for IPAH but also be a potential new therapeutic strategy.<\/jats:p>","DOI":"10.1159\/000348368","type":"journal-article","created":{"date-parts":[[2013,4,9]],"date-time":"2013-04-09T08:32:19Z","timestamp":1365496339000},"page":"241-245","source":"Crossref","is-referenced-by-count":15,"title":["Ghrelin and Its Relation with N-Terminal Brain Natriuretic Peptide, Endothelin-1 and Nitric Oxide in Patients with Idiopathic Pulmonary Hypertension"],"prefix":"10.1159","volume":"124","author":[{"given":"Dan","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhihong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zihe","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2013,4,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.553883"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2009.07.015"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjh.0000163146.20330.bc"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2003.09.085"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1161\/hc3601.095575"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-011-0992-8"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192230"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(98)00296-3"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1378\/chest.129.5.1313"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199701093360207"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejheart.2004.01.004"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2012.02.020"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1378\/chest.120.5.1562"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1378\/chest.120.4.1226"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.02.037"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.8.865"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(97)00452-X"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000149746.62908.BB"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2003.026880"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000102381.57477.50"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.14.1.111"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.74.3.460"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/S1885-5857(06)60489-1"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-0255"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00570.2006"}],"container-title":["Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/348368","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/348368","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/348368","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:55:16Z","timestamp":1745434516000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000348368"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":25,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2013,4,1]]},"published-print":{"date-parts":[[2013,4,23]]}},"URL":"https:\/\/doi.org\/10.1159\/000348368","archive":["Portico"],"relation":{},"ISSN":["0008-6312","1421-9751"],"issn-type":[{"type":"print","value":"0008-6312"},{"type":"electronic","value":"1421-9751"}],"subject":[],"published":{"date-parts":[[2013]]}}}