{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:35:02Z","timestamp":1787754902849,"version":"build-2784847793"},"reference-count":19,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2013]]},"abstract":"<b><i>Background:<\/i><\/b> The neurovascular unit encompasses the functional interactions of cerebrovascular and brain parenchymal cells necessary for the metabolic homeostasis of neurons. Previous studies indicated marked but only transient (1-4 h) reactive oxygen species-dependent neurovascular dysfunction in newborn pigs after severe hypoxic\/ischemic (H\/I) stress contributing to the neuronal injury after birth asphyxia. <b><i>Objectives:<\/i><\/b> Our major purpose was to determine if neurovascular dysfunction would also occur later, at 24 h after a milder H\/I stress. We also tested if the putative hydroxyl radical scavenger hydrogen (H<sub>2<\/sub>) exerted neurovascular protection. <b><i>Methods:<\/i><\/b> Anesthetized, ventilated piglets were assigned to three groups of 9 animals: time control, asphyxia\/reventilation with air, and asphyxia\/reventilation with air +2.1% H<sub>2<\/sub> for 4 h. Asphyxia was induced by suspending ventilation for 8 min. Cerebrovascular reactivity (CR) of pial arterioles was determined using closed cranial window\/intravital microscopy 24 h after asphyxia to the endothelium-dependent cerebrovascular stimulus hypercapnia, the neuronal function-dependent stimulus N-methyl-<smlcap>D<\/smlcap>-aspartate (NMDA), norepinephrine, and sodium nitroprusside. The brains were subjected to histopathology. <b><i>Results:<\/i><\/b> Hemodynamic parameters, blood gases, and core temperature did not differ significantly among the experimental groups. In the early reventilation period, the recovery of electroencephalographic activity was significantly better in H<sub>2<\/sub>-treated animals. Asphyxia\/reventilation severely attenuated CR to hypercapnia and NMDA; however, reactivity to norepinephrine and sodium nitroprusside were unaltered. H<sub>2<\/sub> fully or partially preserved CR to hypercapnia or NMDA, respectively. Histopathology revealed modest neuroprotection afforded by H<sub>2<\/sub>. <b><i>Conclusions:<\/i><\/b> Severe stimulus-selective delayed neurovascular dysfunction develops and persists even after mild H\/I stress. H<sub>2<\/sub> alleviates this delayed neurovascular dysfunction that can contribute to its neuroprotective effect.<\/jats:p>","DOI":"10.1159\/000348445","type":"journal-article","created":{"date-parts":[[2013,7,10]],"date-time":"2013-07-10T08:05:04Z","timestamp":1373443504000},"page":"79-86","source":"Crossref","is-referenced-by-count":21,"title":["Delayed Neurovascular Dysfunction Is Alleviated by Hydrogen in Asphyxiated Newborn Pigs"],"prefix":"10.1159","volume":"104","author":[{"given":"Orsolya","family":"Ol\u00e1h","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9ria","family":"T\u00f3th-Sz\u0171ki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"Temesv\u00e1ri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferenc","family":"Bari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferenc","family":"Domoki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2013,7,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa0900854"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159%2F000329818"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1203%2F00006450-198902000-00020"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.27.10.1874"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097%2F00001756-200112210-00041"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1203%2F00006450-199412000-00003"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159%2F000326270"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.27.9.1634"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038%2Fnm1577"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmj.4.5682.545-a"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.20.4.541"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1080%2F08035250600717139"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.brainresrev.2007.05.011"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1203%2F01.pdr.0000214891.35363.6a"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.brainres.2008.11.048"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007%2F978-3-7091-0693-8_40"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.earlhumdev.2010.05.013"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1159%2F000302718"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.siny.2006.07.011"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/348445","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/348445","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:55:34Z","timestamp":1745434534000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000348445"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":19,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2013,8,1]]},"published-print":{"date-parts":[[2013,8,12]]}},"URL":"https:\/\/doi.org\/10.1159\/000348445","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}