{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:35:49Z","timestamp":1745469349703,"version":"3.40.4"},"reference-count":9,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncol Res Treat"],"published-print":{"date-parts":[[2013]]},"abstract":"<b><i>Purpose:<\/i><\/b> Aim of this study was to evaluate the impact of computed tomography (CT)-based simulation and planning on early glottic cancer outcomes and toxicity. <b><i>Methods:<\/i><\/b> This is a single-institution retrospective study of 253 patients with T1-2 glottic cancer who underwent radiation therapy (RT) from January 1998-2010. Group A (80%) underwent 2-dimensional RT (2DRT) and group B (20%) 3-dimensional RT (3DRT). 76% of patients in group A and 84% in group B had T1 cancer. The median dose and fraction size were 63 Gy and 2.25 Gy, respectively. <b><i>Results:<\/i><\/b> With a median follow-up of 83, 93, and 30 months for the whole cohort, group A and B, respectively, the loco-regional control (LRC) was 97.6%. The rate of LRC for T1 disease was 99.5% and for T2 disease 91%. According to the RT modality, rates of LRC were 99.4 and 100% in groups A and B for T1, and 89.8 and 100% for T2. Long-term toxicity was negligible in both groups. Kaplan-Meier Curve showed the 5-year cause-specific survival to be 100%. Chi-square and multivariate analysis tests showed a significant relationship between CT simulation (3DRT) and LRC (p < 0.0001). <b><i>Conclusion:<\/i><\/b> CT-based simulation and planning provided better LRC and less acute side effects compared to 2DRT.<\/jats:p>","DOI":"10.1159\/000348529","type":"journal-article","created":{"date-parts":[[2013,3,7]],"date-time":"2013-03-07T08:32:25Z","timestamp":1362645145000},"page":"83-86","source":"Crossref","is-referenced-by-count":0,"title":["The Impact of Computed Tomography on Early Glottic Cancer Outcomes"],"prefix":"10.1159","volume":"36","author":[{"given":"Waleed F.","family":"Mourad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth S.","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rania A.","family":"Shourbaji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Ishihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilson","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahesh","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dukagjin M.","family":"Blakaj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis B.","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2013,2,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(98)00062-5"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20181"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(97)00284-8"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.06.014"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2007.08.001"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.05.046"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.06.858"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.6546"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.1.282"}],"container-title":["Oncology Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/348529","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/348529","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:56:07Z","timestamp":1745434567000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000348529"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":9,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2013,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000348529","archive":["Portico"],"relation":{},"ISSN":["2296-5270","2296-5262"],"issn-type":[{"type":"print","value":"2296-5270"},{"type":"electronic","value":"2296-5262"}],"subject":[],"published":{"date-parts":[[2013]]}}}