{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:35:49Z","timestamp":1745469349709,"version":"3.40.4"},"reference-count":19,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncology"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; The effectiveness of palonosetron without delayed dexamethasone dosing against emesis was investigated in patients scheduled to receive the corticosteroid-containing combination of doxorubicin and paclitaxel (AT) for 3 cycles. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Chemo-na\u00efve women with breast cancer receiving doxorubicin (60 mg\/m&lt;sup&gt;2&lt;\/sup&gt;) and paclitaxel (200 mg\/m&lt;sup&gt;2&lt;\/sup&gt;) were eligible. Patients received palonosetron 0.25 mg intravenously before chemotherapy, however, all patients also received a premedication consisting of prednisone (25 mg orally the evening before therapy) and hydrocortisone (250 mg intravenously just before paclitaxel). The primary end point was complete control (CC; no vomiting, no rescue anti-emetics, and no more than mild nausea) during the overall phase (days 1-5) following cycle 1. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Seventy-six patients were enrolled and evaluable (median age 50 years). Fifty-six patients (74%; 95% CI 62-83%) achieved overall CC. Acute (day 1) and delayed (days 2-5) CC rates were 78 and 74%, respectively. No vomiting rates for the acute, delayed and overall phases were 85, 85 and 83%, respectively. An exploratory analysis showed only a small decrease in the probability of achieving CC between cycle 1 (74%) and cycle 3 (66%). &lt;b&gt;&lt;i&gt;Conclusion&lt;\/i&gt;&lt;\/b&gt;: The dexamethasone-sparing strategy prevented emesis in more than 70% of breast cancer patients receiving their initial cycle of AT chemotherapy.<\/jats:p>","DOI":"10.1159\/000348538","type":"journal-article","created":{"date-parts":[[2013,5,22]],"date-time":"2013-05-22T09:45:36Z","timestamp":1369215936000},"page":"371-377","source":"Crossref","is-referenced-by-count":3,"title":["Is a Dexamethasone-Sparing Strategy Capable of Preventing Acute and Delayed Emesis Caused by Combined Doxorubicin and Paclitaxel for Breast Cancer? Analysis of a Phase II Trial"],"prefix":"10.1159","volume":"84","author":[{"given":"Silvia","family":"Damian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Celio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"De Benedictis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Mariani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Agustoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Ricchini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filippo","family":"De Braud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2013,5,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0706547"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.34.4614"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq194"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603048"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/88.7.463"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/87.15.1169"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1700\/1125.12393"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdg417"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11817"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70313-9"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-010-0941-7"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdp584"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.2307\/2530297"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1998.244"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-010-1036-1"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23594"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(05)70325-9"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-009-0723-2"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.12-9-1143"}],"container-title":["Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/348538","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/348538","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/348538","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:56:13Z","timestamp":1745434573000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000348538"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":19,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2013,6,1]]},"published-print":{"date-parts":[[2013,6,5]]}},"URL":"https:\/\/doi.org\/10.1159\/000348538","archive":["Portico"],"relation":{},"ISSN":["0030-2414","1423-0232"],"issn-type":[{"type":"print","value":"0030-2414"},{"type":"electronic","value":"1423-0232"}],"subject":[],"published":{"date-parts":[[2013]]}}}