{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T07:56:01Z","timestamp":1787903761528,"version":"build-2784847793"},"reference-count":23,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemotherapy"],"published-print":{"date-parts":[[2013]]},"abstract":"<b><i>Background:<\/i><\/b> To define the maximum tolerated dose (MTD) tolerability and efficacy of intra-arterial chemotherapy with irinotecan in patients with liver metastases of colorectal carcinoma (CRC). <b><i>Methods:<\/i><\/b> Superselective intra-arterial irinotecan was applied on days 1, 14, 28 and 42. The initial dose was 140 mg\/m<sup>2<\/sup> with escalation in the subsequent patient group to 160 mg\/m<sup>2<\/sup>. The final protocol toxicity evaluation was 260 mg\/m<sup>2<\/sup>. Patients required histologically proven disease and adequate bone marrow, liver and renal function, no extrahepatic metastasis and a life expectancy >12 weeks. <b><i>Results:<\/i><\/b> Thirty-three patients were enrolled (median age 65, range 49-78 years). On dose level VI (240 mg\/m<sup>2<\/sup>), 1 case of dose-limiting toxicity (DLT) (granulocytopenia) was observed, leading to an enlarged cohort of 6 patients. As no additional DLT was detected on this level, an escalation to level VII was performed. On the dose level of 260 mg\/m<sup>2<\/sup>, irinotecan DLTs were observed, resulting in the termination of escalation and the declaration of dose level VI as MTD. Imaging follow-up with Response Evaluation Criteria in Solid Tumors (RECIST) criteria revealed a complete response in 1 patient, stable disease in 31 patients, and progressed disease in 1 patient. The median time to progression was 4.7 months, the median overall survival 15.6 months. <b><i>Conclusion:<\/i><\/b> The method of intra-arterial chemotherapy with irinotecan is well tolerated and shows promising local response rates in liver metastases of CRC.<\/jats:p>","DOI":"10.1159\/000348579","type":"journal-article","created":{"date-parts":[[2013,7,3]],"date-time":"2013-07-03T08:10:43Z","timestamp":1372839043000},"page":"66-73","source":"Crossref","is-referenced-by-count":12,"title":["Hepatic Arterial Infusion with Irinotecan in Patients with Liver Metastases of Colorectal Cancer: Results of an Extended Phase I Study"],"prefix":"10.1159","volume":"59","author":[{"given":"K.","family":"Eichler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Dufas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Hammerstingl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Gruber-Rouh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.J.","family":"Vogl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Zangos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2013,7,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.suc.2003.12.005"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1463-1318.2003.00410.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00104-005-1047-5"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1200%2FJCO.2005.12.039"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1148%2Fradiol.2302020646"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00330-005-2713-1"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00330-005-0131-z"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1200%2FJCO.2004.05.113"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2800%2902034-1"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ctrv.2004.04.002"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-0142%2819960401%2977%3A7%3C1254%3A%3AAID-CNCR5%3E3.0.CO%3B2-I"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002%2Fbjs.1800720514"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097%2F00000658-199909000-00004"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1093%2Fannonc%2Fmdh217"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1200%2FJCO.2002.12.075"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1159%2F000323624"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002%2F1097-0142%28196205%2F06%2915%3A3%3C472%3A%3AAID-CNCR2820150307%3E3.0.CO%3B2-S"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM196402132700701"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1053%2Fsonc.2002.31679"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1200%2FJCO.2005.05.120"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1200%2FJCO.2005.07.100"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1093%2Fannonc%2Fmdh022"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016%2FS0960-7404%2802%2900032-4"}],"container-title":["Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/348579","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/348579","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/348579","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:56:52Z","timestamp":1745434612000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000348579"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":23,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2013,8,1]]},"published-print":{"date-parts":[[2013,8,5]]}},"URL":"https:\/\/doi.org\/10.1159\/000348579","archive":["Portico"],"relation":{},"ISSN":["0009-3157","1421-9794"],"issn-type":[{"value":"0009-3157","type":"print"},{"value":"1421-9794","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}