{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:35:53Z","timestamp":1745469353615,"version":"3.40.4"},"reference-count":16,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncol Res Treat"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background: &lt;\/i&gt;&lt;\/b&gt;Chronic myeloid leukemia (CML) is usually diagnosed in the chronic phase. An extramedullary blast crisis mimicking a T-cell lymphoma is a rare finding. &lt;b&gt;&lt;i&gt;Case Report: &lt;\/i&gt;&lt;\/b&gt;A 35-year-old man presented with multiple lymphadenopathy 2 months after diagnosis of Philadelphia chromosome (Ph)-positive CML in the chronic phase. Cervical lymph node biopsy later indicated an extramedullary blast crisis resembling T-cell lymphoblastic lymphoma (TLBL). The tumor mass was composed of primitive lymphoid cells expressing terminal deoxynucleotidyl transferase (TdT), CD3, CD43, CD5, CD99, and Bcl-2. Although the pathological diagnosis, confirmed by 2 independent pathological centers, was more typical of TLBL, fluorescence in situ hybridization (FISH) analysis showed the &lt;i&gt;bcr-abl&lt;\/i&gt; fusion gene within the blastic tumor cells. The FISH finding confirmed that the mass represented an extramedullary, immature blastic transformation of CML rather than a de novo T-cell lymphoma. &lt;b&gt;&lt;i&gt;Conclusion: &lt;\/i&gt;&lt;\/b&gt;The diagnosis of de novo TLBL should be suspected before excluding the extramedullary blast phase of CML.<\/jats:p>","DOI":"10.1159\/000348681","type":"journal-article","created":{"date-parts":[[2013,3,7]],"date-time":"2013-03-07T08:32:25Z","timestamp":1362645145000},"page":"119-122","source":"Crossref","is-referenced-by-count":11,"title":["Sudden Extramedullary Blast Crisis of Chronic Myeloid Leukemia Manifesting as T-Cell Lymphoblastic Lymphoma"],"prefix":"10.1159","volume":"36","author":[{"given":"Jia","family":"Wei","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianfeng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2013,2,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159\/000084448"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19910801)68:3<605::AID-CNCR2820680327>3.0.CO;2-Y"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2002.126190"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19870115)59:2<297::AID-CNCR2820590221>3.0.CO;2-B"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(87)90754-6"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-2126(96)00054-9"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1701430"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1993.tb03081.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830420218"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1080\/08880010701198787"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1994.tb05050.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1309\/GTGTEQAFMV30W753"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401606"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20025"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2004.03.005"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-12-261586"}],"container-title":["Oncology Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/348681","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/348681","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:57:55Z","timestamp":1745434675000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000348681"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":16,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2013,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000348681","archive":["Portico"],"relation":{},"ISSN":["2296-5270","2296-5262"],"issn-type":[{"type":"print","value":"2296-5270"},{"type":"electronic","value":"2296-5262"}],"subject":[],"published":{"date-parts":[[2013]]}}}