{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T11:41:44Z","timestamp":1790336504966,"version":"4.1.0"},"reference-count":16,"publisher":"S. Karger AG","issue":"1-2","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Neurol"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Disturbed sleep is a core feature of narcolepsy with cataplexy (NC). Few studies have independently assessed sleep-disordered breathing (SDB) and periodic limb movements (PLMs) in non-homogeneous series of patients with and without cataplexy. We systematically assessed both SDB and PLMs in well-defined NC patients. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; We analyzed the clinical and polysomnographic features of 35 consecutive NC patients (mean age 40 \u00b1 16 years, 51% males, 23\/23 hypocretin-deficient) to assess the prevalence of SDB (apnea-hypopnea index &gt;5) and PLMs (periodic leg movements in sleep (PLMI) &gt;15) together with their impact on nocturnal sleep and daytime sleepiness using the multiple sleep latency test. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; 11 (31%) and 14 (40%) patients had SDB and PLMs, respectively. SDB was associated with older age (49 \u00b1 16 vs. 35 \u00b1 13 years, p = 0.02), higher BMI (30 \u00b1 5 vs. 27 \u00b1 6, p = 0.05), and a trend towards higher PLMI (25 \u00b1 20 vs. 12 \u00b1 23, p = 0.052), whereas PLMs with older age (50 \u00b1 16 vs. 33 \u00b1 11 years, p = 0.002) and reduced and fragmented sleep (e.g. sleep efficiency of 82 \u00b1 12% vs. 91 \u00b1 6%, p = 0.015; sleep time of 353 \u00b1 66 vs. 395 \u00b1 28, p = 0.010). SDB and PLMs were also mutually associated (p = 0.007), but not correlated to daytime sleepiness. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; SDB and PLMs are highly prevalent and associated in NC. Nevertheless, SDB and PLMs are rarely severe, suggesting an overall limited effect on clinical manifestations.<\/jats:p>","DOI":"10.1159\/000348719","type":"journal-article","created":{"date-parts":[[2013,5,8]],"date-time":"2013-05-08T08:01:27Z","timestamp":1368000087000},"page":"22-26","source":"Crossref","is-referenced-by-count":45,"title":["Sleep-Disordered Breathing and Periodic Limb Movements in Narcolepsy with Cataplexy: A Systematic Analysis of 35 Consecutive Patients"],"prefix":"10.1159","volume":"70","author":[{"given":"Fabio","family":"Pizza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Tartarotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rositsa","family":"Poryazova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian R.","family":"Baumann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio L.","family":"Bassetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2013,5,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2007.08.010"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(78)90204-3"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2009.02.009"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2869.2007.00601.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2869.2000.00217.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2006.01473.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2006.01.001"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1819.2002.00962.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.162.8.893"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00679.2006"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00919.2007"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2009.03.006"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2007.06.004"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-1563"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000101725.34089.1E"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61622-0"}],"container-title":["European Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/348719","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/348719","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:58:04Z","timestamp":1745434684000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000348719"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":16,"journal-issue":{"issue":"1-2","published-online":{"date-parts":[[2013,8,1]]},"published-print":{"date-parts":[[2013,8,21]]}},"URL":"https:\/\/doi.org\/10.1159\/000348719","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.5124757","asserted-by":"subject"}]},"ISSN":["0014-3022","1421-9913"],"issn-type":[{"value":"0014-3022","type":"print"},{"value":"1421-9913","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}