{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T14:10:56Z","timestamp":1776089456431,"version":"3.50.1"},"reference-count":23,"publisher":"S. Karger AG","issue":"1-2","license":[{"start":{"date-parts":[[2013,3,21]],"date-time":"2013-03-21T00:00:00Z","timestamp":1363824000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,3,21]],"date-time":"2013-03-21T00:00:00Z","timestamp":1363824000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron Clin Pract"],"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background\/Aims:&lt;\/i&gt;&lt;\/b&gt; For most people with chronic kidney disease (CKD), cardiovascular disease (CVD) risk exceeds risk of progression to end-stage renal disease. This study aimed to investigate the distribution of cardiovascular risk in CKD stage 3 by socio-economic status (SES; measured by area deprivation and educational attainment) and CKD diagnosis awareness. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; 1,741 patients with CKD 3 recruited from primary-care practices for the Renal Risk in Derby Study were assessed for cardiovascular risk factors. Ten-year cardiovascular risk, estimated using Framingham and QRISK2 risk prediction algorithms in eligible subgroups, was dichotomised at \u226520% (a threshold for clinical action in the UK), and compared by SES and awareness of CKD diagnosis using logistic regression. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Patients with lower SES had greater adjusted odd ratios (OR) of smoking, diabetes and previous CVD, but not of central obesity, hypertension, elevated total\/high-density-lipoprotein cholesterol ratio or albuminuria. Using Framingham scoring (n = 672), the adjusted OR of having \u226520% 10-year risk were 2.87 [95% confidence interval (CI) 1.41-5.84] in the lowest deprivation quintile compared to the highest, 2.52 (95% CI: 1.52-4.00) in those without qualifications compared to those with qualifications, and 1.54 (95% CI: 1.09-2.17) in those unaware of their CKD diagnosis compared to those aware of it. QRISK2 scoring (n = 1,071) showed a similar association with education status [OR: 2.45 (95% CI: 1.63-3.67)] and lack of CKD awareness [OR: 1.46 (95% CI: 1.05-2.03)], but not with deprivation [OR: 1.12 (95% CI: 0.55-2.27)]. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; An elevated CVD risk is associated with a lower education status and lack of awareness of CKD diagnosis in people with CKD 3.<\/jats:p>","DOI":"10.1159\/000348835","type":"journal-article","created":{"date-parts":[[2013,3,21]],"date-time":"2013-03-21T13:44:48Z","timestamp":1363873488000},"page":"58-65","source":"Crossref","is-referenced-by-count":9,"title":["Socio-Economic Disparities in the Distribution of Cardiovascular Risk in Chronic Kidney Disease Stage 3"],"prefix":"10.1159","volume":"122","author":[{"given":"Simon D.S.","family":"Fraser","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul J.","family":"Roderick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natasha J.","family":"McIntyre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Harris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher W.","family":"McIntyre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard J.","family":"Fluck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maarten W.","family":"Taal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2013,3,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa041031"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl455"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.22.2659"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c4986"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005101085"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfs371"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e256"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2010.09.018"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159\/000329109"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000095676.90936.80"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1136\/jech.2003.013011"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1136\/jech.55.12.895"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159\/000320341"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.17.1884"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfq848"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1159\/000325669"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c2442"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39609.449676.25"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2005.04.033"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3399\/bjgp09X472584"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60739-3"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr599"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.3399\/bjgp12X636047"}],"container-title":["Nephron Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/348835","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/348835","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:12:33Z","timestamp":1745431953000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000348835"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,21]]},"references-count":23,"journal-issue":{"issue":"1-2","published-online":{"date-parts":[[2013,4,1]]},"published-print":{"date-parts":[[2013,4,12]]}},"URL":"https:\/\/doi.org\/10.1159\/000348835","archive":["Portico"],"relation":{},"ISSN":["1660-2110"],"issn-type":[{"value":"1660-2110","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,21]]}}}