{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T22:53:38Z","timestamp":1773269618498,"version":"3.50.1"},"reference-count":34,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lifestyle Genomics"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background\/Aims:&lt;\/i&gt;&lt;\/b&gt; It is unknown whether the effect of alcohol consumption on homocysteine (Hcy) is modulated by the methylenetetrahydrofolate reductase (MTHFR) C677T. We explored this hypothesized effect by analyzing cross-sectional data of 1,827 black South Africans. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Total Hcy concentrations were determined by fluorescence polarization immunoassay and the genotype through polymerase chain reaction-based RFLP analysis. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Subjects harboring the 677 TT genotype had the highest Hcy. Among subjects harboring the 677 CC genotype, men had higher Hcy (p = 0.04). Age and gamma-glutamyltransferase (GGT) correlated best (r = 0.26 and r = 0.27; p &lt; 0.05), while the percentage carbohydrate-deficient transferrin and the B vitamins correlated weakly (r &lt; 0.1; p &lt; 0.05) with Hcy. Hcy was positively associated with the reported alcohol intake (p \u2264 0.01). There was no interaction between alcohol consumption and the MTHFR 677 CC or CT genotypes (p &gt; 0.05) for Hcy concentrations; however, an interaction was determined for GGT and the MTHFR genotype (p = 0.02). Age, GGT, gender, MTHFR and vitamin B&lt;sub&gt;6&lt;\/sub&gt; explained 16.8% of the variation in Hcy (p &lt; 0.01). &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; The determined interactions might result in differences in the risk conveyed through Hcy with regard to disease development in those with unfavorable GGT concentrations.<\/jats:p>","DOI":"10.1159\/000348839","type":"journal-article","created":{"date-parts":[[2013,3,27]],"date-time":"2013-03-27T08:13:37Z","timestamp":1364372017000},"page":"61-72","source":"Crossref","is-referenced-by-count":7,"title":["Nutritional Genetics: The Case of Alcohol and the MTHFR C677T Polymorphism in Relation to Homocysteine in a Black South African Population"],"prefix":"10.1159","volume":"6","author":[{"given":"Cornelie","family":"Nienaber-Rousseau","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro T.","family":"Pisa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine S.","family":"Venter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suria M.","family":"Ellis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annamarie","family":"Kruger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah J.","family":"Moss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alida","family":"Melse-Boonstra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. Wayne","family":"Towers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2013,3,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1093%2Falcalc%2F37.5.409"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1136%2Fjech.2007.065607"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1360-0443.1999.9456493.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ypmed.2003.11.027"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1301%2F00296640260184309"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1515%2FCCLM.2007.038"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.4065%2F83.11.1203"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0009-8981%2802%2900174-2"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1373%2Fclinchem.2006.082149"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1124%2Fpr.54.4.599"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2F0741-8329%2893%2990072-V"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0741-8329%2801%2900168-9"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ahj.2009.04.019"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2FS0741-8329%2899%2900044-0"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038%2Fng0595-111"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.28.706.49"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1079%2FPHN19980025"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2FS0021-9150%2899%2900022-2"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2FS0049-3848%2800%2900254-1"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.atherosclerosis.2004.06.003"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1002%2Fajmg.10122"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1515%2FCCLM.2003.158"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2800%2902502-2"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2362.1992.tb01940.x"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2796.1994.tb00856.x"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.83.2.550"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.ejcn.1600468"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.270.22.2693"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1038%2Fki.1997.359"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.cca.2006.08.035"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1093%2Falcalc%2F36.3.189"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2800%2902172-3"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1530-0277.1993.tb00798.x"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1016%2F0006-2952%2894%2990532-0"}],"container-title":["Lifestyle Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/348839","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/348839","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:12:34Z","timestamp":1745431954000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000348839"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":34,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2013,6,1]]},"published-print":{"date-parts":[[2013,6,27]]}},"URL":"https:\/\/doi.org\/10.1159\/000348839","archive":["Portico"],"relation":{},"ISSN":["2504-3161","2504-3188"],"issn-type":[{"value":"2504-3161","type":"print"},{"value":"2504-3188","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}