{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T17:37:16Z","timestamp":1770745036565,"version":"3.49.0"},"reference-count":25,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cerebrovasc Dis"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Obstructive sleep apnoea (OSA) is associated with hypertension, nocturnal blood pressure (BP) surges, and increased risk of stroke. It may therefore also be associated with a higher risk of developing leukoaraiosis. Only few data about the prevalence of leukoaraiosis in patients with OSA, and any association between degrees of severity of either condition, exist. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; We studied patients who were part of a clinical trial (MOSAIC) in minimally symptomatic OSA. All patients had brain MRI (T2, FLAIR) at baseline. A single observer assessed the images for the presence and severity of leukoaraiosis (ARWMC-score). We related the extent of leukoaraiosis to the severity of OSA (measured by oxygen desaturation index [ODI]) and the presence of other vascular risk factors. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; 183 patients (156 men, 85.2%; mean age \u00b1 SD = 57.7 \u00b1 7.4 years; median oxygen desaturation index = 9.6, interquartile range = 4.6-16.0) took part in the study. Although 135 (74%) patients had some leukoaraiosis, this was generally mild. We confirmed the well-known risk factor associations between leukoaraiosis, increasing age (p &lt; 0.0001) and hypertension (p = 0.003), but we did not find any association between OSA and leukoaraiosis (p = 0.33), despite both conditions being associated with increasing current BP and a history of hypertension. &lt;b&gt;&lt;i&gt;Conclusion: &lt;\/i&gt;&lt;\/b&gt;Our data confirm the well-known association between leukoaraiosis, age and increasing BP. However, we found no association between OSA and leukoaraiosis despite some shared risk factor associations. Our findings suggest that OSA is not a strong independent risk factor for leukoaraiosis. Confounding by hypertension may explain any apparent association in previously reported studies of patients with severer OSA.<\/jats:p>","DOI":"10.1159\/000348845","type":"journal-article","created":{"date-parts":[[2013,4,30]],"date-time":"2013-04-30T14:53:03Z","timestamp":1367333583000},"page":"363-369","source":"Crossref","is-referenced-by-count":17,"title":["Leukoaraiosis on MRI in Patients with Minimally Symptomatic Obstructive Sleep Apnoea"],"prefix":"10.1159","volume":"35","author":[{"given":"Ursula G.","family":"Schulz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca H.","family":"Mason","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonya E.","family":"Craig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sally","family":"Howard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah J.","family":"Nicoll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malcolm","family":"Kohler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter M.","family":"Rothwell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John R.","family":"Stradling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2013,4,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1136\/postgradmedj-2011-130307"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.26.7.1293"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.28.3.652"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159\/000334498"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159\/000341404"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1136\/thx.46.2.85"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2010.145"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)71141-7"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2109080"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)07445-7"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000086818.57992.B8"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200608-1141OC"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.150912.13"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.04.00100203"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200712-1884OC"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.32.6.1318"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60308-X"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.70.1.9"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000132193.35955.69"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1080\/08037050500364117"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000145857.98904.20"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.961052"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-012-6546-y"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201106-0964OC"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.71.3.334"}],"container-title":["Cerebrovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/348845","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/348845","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:12:37Z","timestamp":1745431957000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000348845"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":25,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2013,5,1]]},"published-print":{"date-parts":[[2013,5,16]]}},"URL":"https:\/\/doi.org\/10.1159\/000348845","archive":["Portico"],"relation":{},"ISSN":["1015-9770","1421-9786"],"issn-type":[{"value":"1015-9770","type":"print"},{"value":"1421-9786","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}