{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T15:20:07Z","timestamp":1781623207427,"version":"3.54.5"},"reference-count":16,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2013]]},"abstract":"<b><i>Background:<\/i><\/b> Photodynamic therapy (PDT) is an excellent treatment option for actinic keratosis. However the side effects lead to an impairment of the patients' quality of life. <b><i>Objectives:<\/i><\/b> To evaluate the impact of PDT on patients' quality of life and to determine the frequency and intensity of side effects over the course of 4 weeks post PDT. <b><i>Patients and Methods:<\/i><\/b> 22 patients with actinic keratosis in the face were included into this prospective study. Pain was measured using a visual analog scale immediately and 8 h after PDT. The Dermatology Life Quality Index (DLQI) was assessed at screening, after treatment as well as 2 and 4 weeks after PDT. The physician and patient evaluated the intensity of side effects during the treatment, 2 and 4 weeks post PDT. Additionally, the patient documented side effects daily from the 1st to the 14th day after PDT and on day 28 post PDT, using a diary. <b><i>Results:<\/i><\/b> We observed a significant (p < 0.001) increase in the DLQI from 1.6 \u00b1 1.7 prior to PDT to 7.3 \u00b1 4.9 post PDT. The DLQI normalized in the following 4 weeks. Immediately and 8 h after PDT mean pain was 4.3 \u00b1 2.5 and 2.3 \u00b1 2.1. Side effects documented by the patients were erythema (100%), pain, burning, edema (90.9%), itching (86.4%), scaling (81.8%) and pustules (59.1%). No scar formation, hyper-\/hypopigmentation or infections were observed. <b><i>Conclusion:<\/i><\/b> PDT has a significant temporary impact on patients' DLQI. Transitory side effects are common and show typical kinetics.<\/jats:p>","DOI":"10.1159\/000349992","type":"journal-article","created":{"date-parts":[[2013,6,18]],"date-time":"2013-06-18T08:30:35Z","timestamp":1371544235000},"page":"253-259","source":"Crossref","is-referenced-by-count":30,"title":["Dermatology Life Quality Index and Side Effects after Topical Photodynamic Therapy of Actinic Keratosis"],"prefix":"10.1159","volume":"226","author":[{"given":"Patrick","family":"Gholam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena","family":"Kroehl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander H.","family":"Enk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2013,6,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.06.006"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00755143"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1996.310"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10613.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159\/000329025"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.2002.01065.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-007-1363-4"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.08.062"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1994.tb01167.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2010.07547.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2012.02340.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159\/000106577"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1080\/09546630601028737"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.2010.00829.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2008.02803.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08882.x"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/349992","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/349992","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:13:49Z","timestamp":1745432029000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000349992"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":16,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2013,8,1]]},"published-print":{"date-parts":[[2013,8,8]]}},"URL":"https:\/\/doi.org\/10.1159\/000349992","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}