{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T14:58:31Z","timestamp":1791644311783,"version":"4.3.4"},"reference-count":33,"publisher":"S. Karger AG","issue":"2-3","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney Blood Press Res"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background\/Aims: &lt;\/i&gt;&lt;\/b&gt;To determine the effect of arterial blood pressure (BP) reduction on endocan and soluble cell adhesion molecules' (sCAM) plasma concentration and expression of their ligands on circulatory leukocyte subpopulations. &lt;b&gt;&lt;i&gt;Methods: &lt;\/i&gt;&lt;\/b&gt;24 hypertensive subjects of both sexes (age: 53\u00b18 yrs) were treated with Ca-channel blocker, amlodipin (5-10 mg\/day for 8 weeks; to reach BP\u2264139\/89mmHg). The serum sCAMs and endocan concentrations were determined by ELISA kits. Level of ICAM\/VCAM ligands on leukocytes was assessed by flow cytometry. Paired t-test, or t-test were used as appropriate, with Pearson's correlation calculated; p&lt;0.05 was considered significant (SigmaPlot v.11). &lt;b&gt;&lt;i&gt;Results: &lt;\/i&gt;&lt;\/b&gt;sICAM-1 and sVCAM-1 were decreased (p\u22640.001 and p=0.002, respectively), while E-selectin concentration was increased after amlodipin treatment (P=0.014). CD11a\/LFA-1 &lt;i&gt;(ICAM-1 and endocan ligand) &lt;\/i&gt;was significantly increased in all three cell types with BP decrease. CD15 and CD49d\/VLA-4 &lt;i&gt;(VCAM-1 ligand) &lt;\/i&gt;did not change after the treatment. There was significant positive correlation of systolic and diastolic BP with ICAM-1 and VCAM-1, and significant negative correlation of systolic BP with CD11a\/LFA-1. Endocan significantly positively correlated with ICAM-1. &lt;b&gt;&lt;i&gt;Conclusions: &lt;\/i&gt;&lt;\/b&gt;The increased expression of ICAM\/VACM ligands, together with decrease of sCAMs and endocan suggests the de-activation of endothelium with reduction in BP, decreasing the adherence of circulatory leukocytes to endothelium; subsequently decreasing the risk for development of atherosclerosis.<\/jats:p>","DOI":"10.1159\/000350064","type":"journal-article","created":{"date-parts":[[2013,4,12]],"date-time":"2013-04-12T07:27:08Z","timestamp":1365751628000},"page":"103-115","source":"Crossref","is-referenced-by-count":49,"title":["The Effects of Arterial Blood Pressure Reduction on Endocan and Soluble Endothelial Cell Adhesion Molecules (CAMs) and CAMs Ligands Expression in Hypertensive Patients on Ca-Channel Blocker 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