{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:33:45Z","timestamp":1745469225989,"version":"3.40.4"},"reference-count":21,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathobiology"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; The insulin-like growth factor (IGF) system has been known to play a critical role in tumor development and progression in many human cancers. However, the role of the IGF system in small intestinal carcinoma (SIC) has not been studied yet. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; We evaluated the expression of IGF1 and IGF1 receptor (IFG1R) in a total of 194 cases of SIC. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; IGF1 expression was associated with well\/moderate differentiation, better survival, lower pT, lower stage and no lymph node metastasis. IGF1R was more diffusely and strongly expressed in tumors with lower pT and lower stage. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; IGF1 and IGF1R expression is associated with favorable clinicopathologic parameters and may involve early carcinogenesis of SICs. Target therapy for the IGF1R signaling pathway may not have a major therapeutic role in treating SIC.<\/jats:p>","DOI":"10.1159\/000350309","type":"journal-article","created":{"date-parts":[[2013,5,16]],"date-time":"2013-05-16T07:13:24Z","timestamp":1368688404000},"page":"265-270","source":"Crossref","is-referenced-by-count":1,"title":["Expression of Insulin-Like Growth Factor 1 and Insulin-Like Growth Factor 1 Receptor is Associated with the Favorable Clinicopathologic Parameters in Small Intestinal Carcinomas"],"prefix":"10.1159","volume":"80","author":[{"given":"Hyung Chan","family":"Shin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Kyung","family":"Bae","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mi Jin","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Sun","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young-Ha","family":"Oh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"The Korean Small Intestinal Cancer Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2013,5,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2010.223"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2010.01.006"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25247"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2009.48"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-8-117"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdn040"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/PL00000735"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210464"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.2174\/156800908785133169"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0803383105"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2012.77"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(03)00291-0"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2010.191"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2005.028480"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgl247"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1309\/G7PY0RE7T86HHQYV"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-011-1605-0"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2012.04255.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(99)90027-8"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-0430"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-0875"}],"container-title":["Pathobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/350309","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/350309","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:16:28Z","timestamp":1745432188000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000350309"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":21,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2013,6,1]]},"published-print":{"date-parts":[[2013,6,3]]}},"URL":"https:\/\/doi.org\/10.1159\/000350309","archive":["Portico"],"relation":{},"ISSN":["1015-2008","1423-0291"],"issn-type":[{"type":"print","value":"1015-2008"},{"type":"electronic","value":"1423-0291"}],"subject":[],"published":{"date-parts":[[2013]]}}}