{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T15:18:54Z","timestamp":1783610334946,"version":"3.55.0"},"reference-count":22,"publisher":"S. Karger AG","issue":"Suppl. 2","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>Background: Total and specific immunoglobulin E (IgE) in nasal polyps (NP) is related to local eosinophilic inflammation. However, it remains unclear which antigens cause a stronger accumulation of eosinophils in NP. We investigated whether local IgEs to specific antigens correlated with local eosinophil accumulation. Methods: Total IgE, antigen-specific IgEs [5 species of fungi, staphylococcal enterotoxins A and B (SEA and SEB), cedar pollen, ragweed pollen and house-dust mites] and eosinophil cationic protein (ECP) were measured in sinus mucosa homogenates and serum from 29 patients with chronic rhinosinusitis with NP (CRSwNP), 8 patients with allergic fungal rhinosinusitis (AFRS) and 8 control subjects without CRS. The level of ECP in NP was analyzed for correlations with the total and specific IgE levels in the serum and NP. Results: In CRSwNP, antigen-specific IgEs [Alternaria &gt; mite (Dp) &gt; Aspergillus &gt; SEB &gt; Penicillium &gt; mite (Df), but not the other fungi, SEA or pollens] in the sinus mucosa correlated significantly with the local ECP. In AFRS, antigen-specific IgEs [Penicillium &gt; mite (Df) &gt; Alternaria, but not the other fungi, SEs or pollens] in the sinus mucosa correlated significantly with the local ECP. Conclusions: Local total IgE and antigen (fungi, mites and SEs)-specific IgEs in NP are related to the local eosinophilic inflammation of AFRS and CRSwNP.<\/jats:p>","DOI":"10.1159\/000350387","type":"journal-article","created":{"date-parts":[[2013,5,21]],"date-time":"2013-05-21T09:48:44Z","timestamp":1369129724000},"page":"147-153","source":"Crossref","is-referenced-by-count":21,"title":["Total and Antigen- (Fungi, Mites and Staphylococcal Enterotoxins) Specific IgEs in Nasal Polyps Is Related to Local Eosinophilic Inflammation"],"prefix":"10.1159","volume":"161","author":[{"given":"Yoshinori","family":"Matsuwaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Uno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsushi","family":"Okushi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyoshi","family":"Otori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Moriyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2013,5,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159\/000126066"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1999.tb04381.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(93)90267-J"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199611000-00005"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.112374"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000168111.11802.9c"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2008.22.3227"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2009.03.002"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.09.005"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00074705"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2003.11.023"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.325.7361.411"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199102073240602"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901220"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159\/000327498"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1159\/000337756"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119311"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.1998.00474.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3410\/f.1025203.297767"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.175"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2010.02.018"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1159\/000232566"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/iaa\/article-pdf\/161\/Suppl.%202\/147\/4004997\/000350387.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/iaa\/article-pdf\/161\/Suppl.%202\/147\/4004997\/000350387.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:17:13Z","timestamp":1745432233000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000350387"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":22,"journal-issue":{"issue":"Suppl. 2","published-online":{"date-parts":[[2013,5,1]]},"published-print":{"date-parts":[[2013,5,29]]}},"URL":"https:\/\/doi.org\/10.1159\/000350387","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"value":"1018-2438","type":"print"},{"value":"1423-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}