{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:43:51Z","timestamp":1790397831670,"version":"4.1.0"},"reference-count":26,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Aim:&lt;\/i&gt;&lt;\/b&gt; To compare body composition in children with Prader-Willi syndrome (PWS) not na\u00efve to growth hormone (GH) with obese and lean controls. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Participants included 12 children with PWS, 12 children with obesity (body fat percentage &gt;95th percentile for age and sex) and 12 lean children (body fat percentage &lt;85th percentile for age and sex) matched by age and height. Fat mass, lean mass, bone mineral content (BMC), bone mineral density (BMD) and BMD z-score for total body, hips and lumbar spine were obtained through dual X-ray absorptiometry. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; PWS had higher fat percentage in the legs (p = 0.04) but similar leg fat mass (p = 1.00) compared to obese. PWS exhibited lower lean mass in the body (p = 0.04) and legs (p = 0.02) than obese, but similar to lean (p = 1.00 and p = 0.89, respectively). PWS had lower hip BMC (p &lt; 0.01), BMD (p &lt; 0.01) and BMD z-score (p &lt; 0.01) compared to obese but similar to lean. No other differences were found between PWS and obese (p &gt; 0.05 for all). &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Children with PWS not na\u00efve to GH present differences in fat and lean mass distribution compared to obese controls. BMC and BMD appear unaffected by PWS, except at the hips.<\/jats:p>","DOI":"10.1159\/000350525","type":"journal-article","created":{"date-parts":[[2013,4,24]],"date-time":"2013-04-24T08:09:48Z","timestamp":1366790988000},"page":"271-276","source":"Crossref","is-referenced-by-count":18,"title":["Update on Body Composition and Bone Density in Children with Prader-Willi Syndrome"],"prefix":"10.1159","volume":"79","author":[{"given":"Daniela A.","family":"Rubin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Cano-Sokoloff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diobel L.","family":"Castner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A.","family":"Judelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Duran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea M.","family":"Haqq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2013,4,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159\/000262530"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-010-1373-4"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-006-0116-1"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-2422"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2008.165"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2006.193"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1556"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2004.01.056"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1017\/S001216220100202X"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.118399"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-1389"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-0454"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159\/000319709"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-0270"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021536"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0803232"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1210\/jc.84.12.4702"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/BF01537962"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2007.185"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s002470050288"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.2008.21.11.1041"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00869.2007"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2006.07.006"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1097\/00004694-200001000-00016"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-0889"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1007\/BF01880413"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/350525","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/350525","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:18:42Z","timestamp":1745432322000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000350525"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":26,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2013,6,1]]},"published-print":{"date-parts":[[2013,6,14]]}},"URL":"https:\/\/doi.org\/10.1159\/000350525","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"value":"1663-2818","type":"print"},{"value":"1663-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}