{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:46:23Z","timestamp":1790023583859,"version":"4.0.1"},"reference-count":23,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2013]]},"abstract":"<b><i>Background:<\/i><\/b> Racial and geographic factors seem to affect the incidence of cutaneous and mucosal melanoma. <b><i>Objective:<\/i><\/b> To investigate the occurrence of <i>BRAF<\/i> and <i>cKIT<\/i> impairments in patients with sinonasal melanoma in Southern Italy. <b><i>Methods:<\/i><\/b> Eleven sinonasal melanomas were screened for <i>BRAF<\/i> mutations and <i>cKIT<\/i> alterations by immunohistochemistry (CD117), fluorescence in situ hybridization and sequencing analyses. <b><i>Results:<\/i><\/b> A high prevalence (4\/11; 36%) of <i>BRAF<\/i> mutations and lack of <i>cKIT<\/i> mutations were observed. Amplification of <i>cKIT<\/i> was found in 18% of cases; cKIT expression was detectable in 18% non-overlapping cases. No correlation between CD117 and <i>cKIT<\/i> alterations was observed. One (6%) <i>cKIT<\/i> and two (12%) <i>BRAF<\/i> mutations were detected in an additional series of 17 acral\/mucosal melanomas from the same geographic areas. <b><i>Conclusion:<\/i><\/b> Mutations of <i>cKIT<\/i> are infrequent in sinonasal melanoma in Southern Italy.<\/jats:p>","DOI":"10.1159\/000350683","type":"journal-article","created":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T12:08:29Z","timestamp":1372680509000},"page":"279-284","source":"Crossref","is-referenced-by-count":29,"title":["Unexpected Distribution of <b><i>cKIT<\/i><\/b> and <b><i>BRAF<\/i><\/b> Mutations among Southern Italian Patients with Sinonasal Melanoma"],"prefix":"10.1159","volume":"226","author":[{"given":"Maria","family":"Colombino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelia","family":"Lissia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato","family":"Franco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerardo","family":"Botti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo A.","family":"Ascierto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Manca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria 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