{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T04:22:45Z","timestamp":1782879765009,"version":"3.54.5"},"reference-count":25,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Endobronchial ultrasound-transbronchial nee dle aspiration (EBUS-TBNA) is a useful technique for cytological assessment of enlarged mediastinal lymph nodes with a high diagnostic yield for lung cancer. However, the small sample volume can be problematic in diagnosing benign diseases and for molecular analysis of malignant tumours. &lt;b&gt;&lt;i&gt;Objectives:&lt;\/i&gt;&lt;\/b&gt; The aim of the study was to evaluate a novel lymph node forceps for EBUS-guided lymph node biopsy (EBUS-transbronchial forceps biopsy; EBUS-TBFB) in malignant and benign conditions concerning safety, feasibility, and diagnostic yield. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Patients with enlarged mediastinal or hilar lymph nodes were included. EBUS-TBNA was performed followed by EBUS-guided TBFB with the lymph node forceps. Three biopsy specimens were obtained. The diagnostic yields of EBUS-TBFB, EBUS-TBNA, and the combination of both sampling techniques were compared. Complications were systematically recorded. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Fifty-five patients with enlarged mediastinal nodes were enrolled into this study. Specimens adequate for histological analysis were obtained in all but one case using EBUS-TBFB. EBUS-TBFB increased the diagnostic yield of EBUS-TBNA from 64 to 93% in benign conditions. The overall diagnostic yield was higher compared to EBUS-TBNA alone. EGFR mutation analysis could be achieved in the forceps biopsy samples as needed. No complications were observed. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; EBUS-TBFB with a novel lymph node forceps is safe and provides adequate histological specimens of enlarged mediastinal lymph nodes. EBUS-TBFB increases the diagnostic yield in benign conditions and may add value in molecular analysis of non-small cell lung cancer.<\/jats:p>","DOI":"10.1159\/000350867","type":"journal-article","created":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T07:39:58Z","timestamp":1373960398000},"page":"229-236","source":"Crossref","is-referenced-by-count":52,"title":["Evaluation of a Novel Endobronchial Ultrasound-Guided Lymph Node Forceps in Enlarged Mediastinal Lymph Nodes"],"prefix":"10.1159","volume":"86","author":[{"given":"Kaid","family":"Darwiche","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lutz","family":"Freitag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun","family":"Nair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Neumann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruediger","family":"Karpf-Wissel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Welter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremias","family":"Wohlschlaeger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Theegarten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2013,7,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2011.08.037"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00095404"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2005.047829"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-2535"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.145938"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2007.084079"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00028706"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-0998"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2008.02.031"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2011.03.069"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-011-9341-0"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/LBR.0b013e3181afde66"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/161.5.977"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1378\/chest.126.1.122"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2005.041525"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-2100"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e3181f77b58"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-0095"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2009.07.013"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00033311"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2012.02.014"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.1999.14d02.x"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(97)00324-2"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e3181753b5e"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1159\/000335254"}],"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/350867","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/350867","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:21:45Z","timestamp":1745432505000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000350867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":25,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2013,9,1]]},"published-print":{"date-parts":[[2013,9,24]]}},"URL":"https:\/\/doi.org\/10.1159\/000350867","archive":["Portico"],"relation":{},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"value":"0025-7931","type":"print"},{"value":"1423-0356","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}