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Karger AG","issue":"3-4","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>The relationship between the apolipoprotein E (ApoE) \u03b54 genotype and an increased risk of developing Alzheimer's disease (AD) has been well established in Caucasians but is less established among other ethnicities. ApoE \u03b54 has also been associated with several other neurological disorders. Whether Apo&amp;#x0395;4 \u03b54 is a risk factor for frontotemporal dementia (FTD) remains controversial. This study examined 432 patients with AD, 62 with FTD, and 381 sex- and age-matched controls. The ApoE \u03b54 allele frequency was significantly increased among patients in the AD and FTD groups compared with controls. The frequency of the Apo&amp;#x0395; \u03b54 allele was 24.86% in late-onset AD (p &lt; 0.01), 18.02% in early-onset AD (p &lt; 0.01), 16.13% in FTD (p &lt; 0.01), and 7.34% in controls. Apo&amp;#x0395; \u03b54 prevalence was similar in the FTD and AD groups. The present study suggests that the ApoE \u03b54 allele is a risk factor for both disorders.<\/jats:p>","DOI":"10.1159\/000350872","type":"journal-article","created":{"date-parts":[[2013,7,23]],"date-time":"2013-07-23T07:19:18Z","timestamp":1374563958000},"page":"163-170","source":"Crossref","is-referenced-by-count":31,"title":["Apolipoprotein &amp;#x0395; \u03b54 Frequency Is Increased among Chinese Patients with Frontotemporal Dementia and Alzheimer's Disease"],"prefix":"10.1159","volume":"36","author":[{"given":"Yong","family":"Ji","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya 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