{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T13:38:09Z","timestamp":1780666689883,"version":"3.54.1"},"reference-count":27,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; In neonatal rats, early post-hypoxia-ischemia (HI) administration of the omega-3 fatty acid docosahexaenoic acid (DHA) improves sensorimotor function, but does not attenuate brain damage. &lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; To determine if DHA administration in addition to hypothermia, now standard care for neonatal asphyxial brain injury, attenuates post-HI damage and sensorimotor deficits. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Seven-day-old (P7) rats underwent right carotid ligation followed by 90 min of 8% O&lt;sub&gt;2&lt;\/sub&gt; exposure. Fifteen minutes later, pups received injections of DHA 2.5 mg\/kg (complexed to 25% albumin) or equal volumes of albumin. After a 1-hour recovery, pups were cooled (3 h, 30\u00b0C). Sensorimotor and pathology outcomes were initially evaluated on P14. In subsequent experiments, sensorimotor function was evaluated on P14, P21, and P28; histopathology was assessed on P28. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; At P14, left forepaw function scores (normal: 20\/20) were near normal in DHA + hypothermia-treated animals (mean \u00b1 SD 19.7 \u00b1 0.7 DHA + hypothermia vs. 12.7 \u00b1 3.5 albumin + hypothermia, p &lt; 0.0001) and brain damage was reduced (mean \u00b1 SD right hemisphere damage 38 \u00b1 17% with DHA + hypothermia vs. 56 \u00b1 15% with albumin + hypothermia, p = 0.003). Substantial improvements on three sensorimotor function measures and reduced brain damage were evident up to P28. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Unlike post-HI treatment with DHA alone, treatment with DHA + hypothermia produced both sustained functional improvement and reduced brain damage after neonatal HI.<\/jats:p>","DOI":"10.1159\/000351011","type":"journal-article","created":{"date-parts":[[2013,6,26]],"date-time":"2013-06-26T11:42:30Z","timestamp":1372246950000},"page":"71-78","source":"Crossref","is-referenced-by-count":28,"title":["Docosahexaenoic Acid Augments Hypothermic Neuroprotection in a Neonatal Rat Asphyxia Model"],"prefix":"10.1159","volume":"104","author":[{"given":"Deborah R.","family":"Berman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Mozurkewich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Shangguan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"Barks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faye S.","family":"Silverstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2013,6,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000149620.74770.2e"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1093%2Fbrain%2Fawm223"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jnutbio.2008.06.014"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ajog.2009.01.020"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ajog.2010.06.017"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1440-1789.2010.01114.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1161%2FSTROKEAHA.110.586081"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.M305841200"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmj.c363"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.siny.2010.02.002"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000128029.50221.fa"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1203%2FPDR.0b013e3181d4ff4d"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038%2Fpr.2012.7"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.410090206"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159%2F000075665"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1159%2F000151753"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2FS0028-3908%2800%2900005-8"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2FS0387-7604%2897%2900027-2"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.neuro.2007.08.003"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.resuscitation.2010.01.023"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.273.22.13605"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-079X.2008.00639.x"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1097%2F00004647-200207000-00009"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.neuroscience.2008.05.061"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.0904835106"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.neuint.2011.01.026"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1097%2FMPG.0b013e318182c8f6"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/351011","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/351011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:22:53Z","timestamp":1745432573000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000351011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":27,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2013,7,1]]},"published-print":{"date-parts":[[2013,7,5]]}},"URL":"https:\/\/doi.org\/10.1159\/000351011","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}