{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T12:54:26Z","timestamp":1791032066890,"version":"4.1.0"},"reference-count":20,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2013]]},"abstract":"<b><i>Background:<\/i><\/b> The influence of the first immunization on cardiorespiratory (CR) stability in very preterm infants is still a controversial subject. <b><i>Objectives:<\/i><\/b> To describe the changes induced by immunization on heart and respiratory rate variability (HRV-RRV) and to test a potential association between preimmunization profiles and postimmunization CR events. <b><i>Methods:<\/i><\/b> Continuous 72-hour CR recordings and 2.5-hour polysomnographic recordings were performed on very preterm infants immunized after 7 weeks. The results are expressed as medians (interquartile ranges). <b><i>Results:<\/i><\/b> Immunization was performed on 31 very preterm infants [28 weeks' gestation (26.9-29), birth weight: 965 g (795-1,105)], and was associated with an increased incidence (p < 0.01) of events lasting more than 10 s: bradycardia <80 bpm [2.2 (1.1-7) vs. 1.8 (1-4)\/12 h], desaturation [17.6 (9.4-36.4) vs. 13.9 (7.7-33.8)\/12 h] and associated bradycardia-desaturation [I<sub>B+D<\/sub>, 4.1 (1.4-7.3) vs. 2.4 (1-4.6)\/12 h], with mild changes in HRV and no change in RRV. The changes in I<sub>B+D<\/sub> frequency were correlated with preimmunization I<sub>B+D<\/sub> frequency (r = 0.44, p < 0.05), HRV spectral parameter low frequency\/high frequency ratio (LF\/HF, r = 0.55, p < 0.01) and approximate entropy of HRV (r = -0.39, p < 0.05). <b><i>Conclusion:<\/i><\/b> The increase in CR events after the first immunization in very preterm infants was associated with: (1) sympathetic predominance in heart rate control (high LF\/HF ratio), (2) abnormal oversimplification of HRV (low entropy) and (3) persistent respiratory rhythm control immaturity (high I<sub>B+D<\/sub> before vaccine).<\/jats:p>","DOI":"10.1159\/000351035","type":"journal-article","created":{"date-parts":[[2013,7,24]],"date-time":"2013-07-24T18:38:48Z","timestamp":1374691128000},"page":"151-155","source":"Crossref","is-referenced-by-count":14,"title":["Possible Predictors of Cardiorespiratory Events after Immunization in Preterm Neonates"],"prefix":"10.1159","volume":"104","author":[{"given":"Tiphaine","family":"Mialet-Marty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Beuch\u00e9e","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wissal","family":"Ben Jmaa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nga","family":"N'Guyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Navarro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabienne","family":"Por\u00e9e","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Monique","family":"Nuyt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Pladys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2013,7,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2008.04.037"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1136\/fn.81.1.F67"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2006.09.065"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2008.03.043"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2004.04.006"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-005-1674-3"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2001.tb02457.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-2059"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1186\/cc8132"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00487.2010"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2011.06.044"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/BF02277969"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1136\/fn.85.1.F36"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159\/000208792"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.2206"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2011.00081"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-6-20"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2009.09.543"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-3782(98)00039-5"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1159\/000244052"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/351035","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/351035","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:23:01Z","timestamp":1745432581000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000351035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":20,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2013,8,1]]},"published-print":{"date-parts":[[2013,8,12]]}},"URL":"https:\/\/doi.org\/10.1159\/000351035","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}