{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:27:07Z","timestamp":1759530427188,"version":"3.40.4"},"reference-count":12,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemotherapy"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; This retrospective study aimed to determine whether adverse events are more common in docetaxel followed by cyclophosphamide (TC) as compared to the reverse infusion order (rTC). &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; A retrospective analysis was undertaken at a single institution for 92 consecutive cases&lt;b&gt; &lt;\/b&gt;treated with TC or rTC for stage I-III breast cancer in a neoadjuvant\/adjuvant setting between December 2006 and June 2011. TC was administered during the first 2.5 years and rTC in the latter 2 years. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Among the 92 cases, 50 were in the TC arm and 42 in the rTC arm. Fatigue (72.0 vs. 23.8%), edema (48.0 vs. 16.7%), peripheral neuropathy (66.0 vs. 14.3%), myalgia (48.0 vs. 9.5%) and stomatitis (48.0 vs. 16.7%) occurred significantly more often in cases receiving TC compared to rTC, respectively. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Nonhematological toxicities are less common in cases receiving rTC in comparison to those receiving TC.<\/jats:p>","DOI":"10.1159\/000351112","type":"journal-article","created":{"date-parts":[[2013,9,2]],"date-time":"2013-09-02T06:54:47Z","timestamp":1378104887000},"page":"93-98","source":"Crossref","is-referenced-by-count":2,"title":["Reduction of Toxicity by Reversing the Order of Infusion of Docetaxel and Cyclophosphamide"],"prefix":"10.1159","volume":"59","author":[{"given":"Marie","family":"Hanaoka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidetaka","family":"Kawabata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuguo","family":"Iwatani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshimi","family":"Takano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daishu","family":"Miura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2013,8,31]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.18.4028"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1529-8027.2000.005002118.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.SABCS-79"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.06.5391"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2011.04.001"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159\/000321037"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159\/000313526"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdi058"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3816\/CBC.2007.n.029"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1177\/00912709922008182"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.01.025"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdg118"}],"container-title":["Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/351112","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/351112","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/351112","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:23:22Z","timestamp":1745432602000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000351112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":12,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2013,10,1]]},"published-print":{"date-parts":[[2013,10,14]]}},"URL":"https:\/\/doi.org\/10.1159\/000351112","archive":["Portico"],"relation":{},"ISSN":["0009-3157","1421-9794"],"issn-type":[{"type":"print","value":"0009-3157"},{"type":"electronic","value":"1421-9794"}],"subject":[],"published":{"date-parts":[[2013]]}}}