{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T22:26:29Z","timestamp":1778538389143,"version":"3.51.4"},"reference-count":43,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2013,8,28]],"date-time":"2013-08-28T00:00:00Z","timestamp":1377648000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,8,28]],"date-time":"2013-08-28T00:00:00Z","timestamp":1377648000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Manifestation of central sleep apnea (CSA) with Cheyne-Stokes respiration is of major prognostic impact in chronic heart failure (CHF). Inflammatory processes have been linked to a progression of cardiovascular diseases, including heart failure. While an association of C-reactive protein (CRP) levels to obstructive sleep apnea has been documented before, there is a lack of information regarding variation of CRP levels in patients with CSA. &lt;b&gt;&lt;i&gt;Objectives:&lt;\/i&gt;&lt;\/b&gt; The objective of this study was to investigate a potential association of CRP levels to CSA severity in CHF patients. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; High sensitivity CRP levels were analyzed in 966 patients with CHF (BMI 26.3 \u00b1 4.6, New York Heart Association class 2.6 \u00b1 0.5, left ventricular ejection fraction 29.4 \u00b1 7.9%, N-terminal pro-brain natriuretic peptide, NT-proBNP, level 2,209 \u00b1 3,315 pg\/ml) without sleep-disordered breathing (SDB; Apnea-Hypopnea Index, AHI, &lt;5\/h) or various degrees of CSA, documented by in-hospital cardiorespiratory polygraphy or polysomnography. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; The CRP concentration in CHF patients was 0.550 \u00b1 0.794 mg\/dl in patients without SDB (AHI 0-4\/h, n = 403) versus 0.488 \u00b1 0.708 mg\/dl in patients with mild CSA (AHI 5-14\/h, n = 123, p = n.s.) and 0.660 \u00b1 0.963 mg\/dl in patients with moderate CSA (AHI 15-29\/h, n = 160, p = n.s.). In patients with severe CSA (AHI \u226530\/h, n = 280), significantly higher CRP concentrations were documented (0.893 \u00b1 1.384 mg\/dl, p &lt; 0.05). Stepwise regression analysis revealed AHI, NT-proBNP and heart rate to be independently associated with elevated CRP levels. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Severe CSA in CHF patients is associated with elevated levels of CRP, a systemic marker of inflammation and cardiovascular risk. This might explain in part the negative prognostic impact of CSA in these patients.<\/jats:p>","DOI":"10.1159\/000351115","type":"journal-article","created":{"date-parts":[[2013,8,28]],"date-time":"2013-08-28T14:50:46Z","timestamp":1377701446000},"page":"113-120","source":"Crossref","is-referenced-by-count":21,"title":["C-Reactive Protein Is Elevated in Heart Failure Patients with Central Sleep Apnea and Cheyne-Stokes 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