{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:34:05Z","timestamp":1745469245825,"version":"3.40.4"},"reference-count":16,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"published-print":{"date-parts":[[2013]]},"abstract":"<b><i>Introduction:<\/i><\/b> Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) down-regulation by preferentially expressed antigen of melanoma (PRAME) is a general phenomenon in different types of solid tumours, but research on the correlation between PRAME and TRAIL gene expression in leukaemia patients is rare. <b><i>Method:<\/i><\/b> PRAME and TRAIL expression was detected in bone marrow samples from 80 newly diagnosed acute leukaemia (AL) patients and 40 chronic myeloid leukaemia (CML) patients using TaqMan-based real-time quantitative PCR methods, and a linear correlation analysis was performed on their levels of expression. A total of 15 normal bone marrow samples from individuals with non-malignant haematological diseases served as normal controls. <b><i>Results:<\/i><\/b> PRAME expression was higher in both AL and CML patients compared to controls (both p < 0.001). CML patients in both blast crisis (BC) and the accelerated phase (AP) had significantly higher PRAME levels than CML patients in the chronic phase (CP) (p = 0.006 and 0.0461, respectively). TRAIL expression was higher in both the acute myeloid leukaemia (AML) group and the acute lymphoblastic leukaemia (ALL) group than in the controls (p = 0.039 and 0.047, respectively). In contrast, CML patients had lower TRAIL levels than controls (p = 0.043), and TRAIL expression in CML patients in the advanced phases (BC and AP) was significantly lower than in CML-CP patients (p = 0.006). In CML patients, there was a significant inverse correlation (Spearman's R = -0.6669, p < 0.0001) between PRAME and TRAIL gene expression, while a greater significant inverse correlation was found in patients in the advanced phases (BC and AP) (R = -0.6764). In addition, no correlation was observed in AML and ALL patients. <b><i>Conclusion:<\/i><\/b> The simultaneous detection of PRAME and TRAIL gene expression may be helpful to monitor condition changes in leukaemia patients and evaluate therapeutic effects in clinical practice, particularly in CML patients.<\/jats:p>","DOI":"10.1159\/000351166","type":"journal-article","created":{"date-parts":[[2013,9,2]],"date-time":"2013-09-02T06:54:47Z","timestamp":1378104887000},"page":"297-304","source":"Crossref","is-referenced-by-count":1,"title":["Correlation between Preferentially Expressed Antigen of Melanoma and Tumour Necrosis Factor-Related Apoptosis-Inducing Ligand Gene Expression in Different Types of Leukaemia Patients"],"prefix":"10.1159","volume":"130","author":[{"given":"Wenhui","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaikai","family":"Chi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baogen","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuqing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pingchong","family":"Lei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yulong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2013,8,31]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS1074-7613%2800%2980426-4"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2F1074-7613%2895%2990057-8"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038%2Fonc.2010.409"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1515%2FCCLM.2006.106"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.0510423103"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2141.2001.02670.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2141.1998.00982.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0165-4608%2801%2900570-2"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS0014-5793%2800%2901112-1"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038%2F415530a"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1080%2F10428190802035933"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.cr.7290311"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2141.1999.01630.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291521-4141%28199801%2928%3A01%3C143%3A%3AAID-IMMU143%3E3.0.CO%3B2-3"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.cell.2005.07.003"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.cancergencyto.2007.05.011"}],"container-title":["Acta Haematologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/351166","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/351166","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/351166","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:23:49Z","timestamp":1745432629000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000351166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":16,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2013,11,1]]},"published-print":{"date-parts":[[2013,11,18]]}},"URL":"https:\/\/doi.org\/10.1159\/000351166","archive":["Portico"],"relation":{},"ISSN":["0001-5792","1421-9662"],"issn-type":[{"type":"print","value":"0001-5792"},{"type":"electronic","value":"1421-9662"}],"subject":[],"published":{"date-parts":[[2013]]}}}