{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:34:11Z","timestamp":1745469251265,"version":"3.40.4"},"reference-count":21,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objectives:&lt;\/i&gt;&lt;\/b&gt; To assess correlations between concomitant high-grade prostatic intraepithelial neoplasia (HGPIN), pathological features and oncologic outcomes after radical prostatectomy (RP). &lt;b&gt;&lt;i&gt;Material and Methods:&lt;\/i&gt;&lt;\/b&gt; We prospectively collected a single-institution database of 2,351 patients who underwent RP between 1998 and 2011. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; 1,272 (54.1%) patients had HGPIN on specimens. The mean follow-up was 28 months. Presence of HGPIN was significantly associated with a favorable preoperative risk status and with pathological factors of poor prognosis in RP specimens. Patients without HGPIN had a worse biochemical recurrence-free survival compared with those with HGPIN in RP specimen (log-rank test: p = 0.015). The 3-year RFS rate was 73.9% for the HGPIN group versus 67.2%. The absence of HGPIN was also significantly correlated with the use of androgen deprivation treatment during the follow-up (p &lt; 0.001). In Cox multivariate analysis, taking into account the other prognostic pathological factors, HGPIN was not an independent predictive factor for PSA failure (p = 0.868). &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; HGPIN is associated with factors of good prognosis but fails to show independent significance when classical pathological prognostic factors are taken into account.<\/jats:p>","DOI":"10.1159\/000351319","type":"journal-article","created":{"date-parts":[[2013,7,31]],"date-time":"2013-07-31T09:04:49Z","timestamp":1375261489000},"page":"264-269","source":"Crossref","is-referenced-by-count":2,"title":["Concomitant High-Grade Prostatic Intraepithelial Neoplasia Is Associated with Good Prognosis Factors and Oncologic Outcome after Radical Prostatectomy"],"prefix":"10.1159","volume":"92","author":[{"given":"Alexandre","family":"Ingels","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillaume","family":"Ploussard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yves","family":"Allory","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claude","family":"Abbou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre","family":"de la Taille","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurent","family":"Salomon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2013,8,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpuro0815"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(00)00447-7"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000168178.48535.0d"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)65953-8"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)00337-X"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(97)00249-5"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19880201)61:3<555::AID-CNCR2820610322>3.0.CO;2-H"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.16.2120"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.51.2.96"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3816\/CBC.2005.n.001"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(86)80156-3"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159\/000019882"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.53.9.655"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/BF01621801"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800053"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(97)90097-6"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(92)90104-B"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2005.12.031"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2007.07115.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1097\/00005392-199909010-00035"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3182206da8"}],"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/351319","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/351319","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:25:57Z","timestamp":1745432757000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000351319"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,1]]},"references-count":21,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2014,4,1]]},"published-print":{"date-parts":[[2014,4,17]]}},"URL":"https:\/\/doi.org\/10.1159\/000351319","archive":["Portico"],"relation":{},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"type":"print","value":"0042-1138"},{"type":"electronic","value":"1423-0399"}],"subject":[],"published":{"date-parts":[[2013,8,1]]}}}