{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:04:03Z","timestamp":1789193043221,"version":"build-2803163510"},"reference-count":16,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>We report herein a patient treated with vemurafenib for a stage IV melanoma who developed an eruption related to eccrine squamous syringometaplasia (ESS). This entity is a well-described side effect of cytostatic therapies used for malignant neoplasia and is clinically characterized by a symmetric cutaneous eruption composed of papules and vesicles preferentially located on fold and intertriginous areas. It is histologically defined by a squamous metaplasia of eccrine ductal epithelium. ESS represents another skin eruption to be added to the list of cutaneous adverse events associated with vemurafenib, a selective BRAF inhibitor used to treat patients with metastatic melanoma harboring the V600E mutation. The discussion focuses on the pathogenesis of ESS secondary to vemurafenib and on alternative diagnoses.<\/jats:p>","DOI":"10.1159\/000351320","type":"journal-article","created":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T07:39:58Z","timestamp":1373960398000},"page":"362-364","source":"Crossref","is-referenced-by-count":10,"title":["Vemurafenib-Induced Eccrine Squamous Syringometaplasia"],"prefix":"10.1159","volume":"226","author":[{"given":"A.","family":"Lescoat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Droitcourt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Stock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Le Gall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Dupuy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2013,7,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1979.tb01136.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12010"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103782"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.04.021"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2011.01860.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.02.038"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1202124"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-07-446286"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.06.045"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2012.06.009"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(98)70532-8"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2012.758"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09290.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.10.043"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.07.034"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mds292"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/351320","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/351320","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:25:57Z","timestamp":1745432757000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000351320"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":16,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2013,9,1]]},"published-print":{"date-parts":[[2013,9,6]]}},"URL":"https:\/\/doi.org\/10.1159\/000351320","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}