{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T19:20:31Z","timestamp":1784661631226,"version":"3.55.0"},"reference-count":31,"publisher":"S. Karger AG","issue":"3-4","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Neurol"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Aim:&lt;\/i&gt;&lt;\/b&gt; To investigate the association of hemoglobin A&lt;sub&gt;1c&lt;\/sub&gt; (HbA&lt;sub&gt;1c&lt;\/sub&gt;) with acute diffusion-weighted imaging lesion volumes (DIV) and early neurologic deterioration (END) in brainstem infarctions (BSIs). &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; 152 patients with acute BSIs were included in this study. The relationship between HbA&lt;sub&gt;1c&lt;\/sub&gt; and DIV quartiles was examined. Data considered potentially associated with HbA&lt;sub&gt;1c&lt;\/sub&gt; and END after admission and patients' symptomatic changes prior to admission were collected. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; There was a significant correlation between HbA&lt;sub&gt;1c&lt;\/sub&gt; (%) and DIV (Spearman &amp;#x03C1; = 0.201, p = 0.013). The median HbA&lt;sub&gt;1c&lt;\/sub&gt; (%) values for successive DIV quartiles (lowest to highest quartile) were as follows: 5.90, 6.35, 6.25, and 7.50 (p = 0.033). The incidence of diabetes mellitus had a significant association with DIV quartiles (p = 0.042). HbA&lt;sub&gt;1c&lt;\/sub&gt; was signi&amp;#xFB01;cantly associated with symptomatic progression prior to admission (p = 0.015). 29 patients developed END after admission. Age, HbA&lt;sub&gt;1c&lt;\/sub&gt;, systolic blood pressure, and fibrinogen were signi&amp;#xFB01;cantly associated with END. On logistic regression analysis, HbA&lt;sub&gt;1c&lt;\/sub&gt; and fibrinogen proved to be independent variables. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; HbA&lt;sub&gt;1c&lt;\/sub&gt; may be a possible predictor for ischemic severity, early deterioration of acute BSIs, and short-term prognosis. Long-term good glycemic control is very important in BSIs. Further studies are warranted to confirm these results.<\/jats:p>","DOI":"10.1159\/000351356","type":"journal-article","created":{"date-parts":[[2013,9,2]],"date-time":"2013-09-02T06:54:47Z","timestamp":1378104887000},"page":"225-232","source":"Crossref","is-referenced-by-count":15,"title":["Ischemic Volumes and Early Neurologic Deterioration in Acute Brainstem Infarctions with Hemoglobin 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