{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:34:03Z","timestamp":1790199243741,"version":"4.1.0"},"reference-count":23,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background\/Objective:&lt;\/i&gt;&lt;\/b&gt; Alopecia areata may occur at any age, though usually before the age of 20 years. Treatment often consists of systemic steroids administered as high-dose bolus infusions. This study sought to investigate the effectiveness and side effects of intravenous high-dose pulse corticosteroids in children with alopecia areata and to identify prognostic factors for successful treatment. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Patients treated with pulse corticosteroids for alopecia areata in 2001-2008 at the day care unit of a tertiary pediatric medical center were identified by computerized file search and clinical treatment and outcome data were collected. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; The sample included 24 children (16 female, 8 male) with a mean age of 8.5 \u00b1 4.6 years at diagnosis; 8 (33%) had multifocal disease,10 (42%) multifocal disease with ophiasis, 4 (17%) alopecia totalis and 2 (8%) alopecia universalis. Nail involvement was noted in 9 patients (38%). Mean duration of disease was 22 \u00b1 27 months. Patients were treated with 8 mg\/kg body weight intravenous methylprednisolone on 3 consecutive days at 1-month intervals. After a mean of 5.65 \u00b1 1.95 courses, 9 patients (38%) had a complete response, 7 (29%) a partial response and 8 (33%) no response. Of the 16 responders, 13 (81%) relapsed at 9.5 \u00b1 12 months after the last course; 3 patients had side effects, none of which were severe. Three positive prognostic factors were identified: short disease duration (\u22646 months), younger age at disease onset (&lt;10 years) and multifocal disease (as opposed to severe, diffuse variants). &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Careful patient selection is necessary to achieve maximal benefit from pulse corticosteroid treatment for alopecia areata in children.<\/jats:p>","DOI":"10.1159\/000351559","type":"journal-article","created":{"date-parts":[[2013,9,2]],"date-time":"2013-09-02T02:55:09Z","timestamp":1378090509000},"page":"37-44","source":"Crossref","is-referenced-by-count":43,"title":["Pulse Corticosteroid Therapy for Alopecia Areata in Children: A Retrospective Study"],"prefix":"10.1159","volume":"227","author":[{"given":"Rivka","family":"Friedland","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rotem","family":"Tal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moshe","family":"Lapidoth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Zvulunov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Ben Amitai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2013,8,31]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12471869"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159\/000051642"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1172\/JCI551"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jidsp.5640212"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(00)90164-6"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1996.tb03281.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(98)70009-X"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.10.031"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.10955.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159\/000092287"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159\/000107626"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08458.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2010.01135.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.1998.tb01348.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.10.873"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.01727.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.05.008"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1976.01630350025006"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(94)70043-5"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.06.027"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-008-0210-7"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.annder.2010.06.031"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1159\/000339341"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/351559","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/351559","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T14:28:02Z","timestamp":1745418482000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000351559"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":23,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2013,10,1]]},"published-print":{"date-parts":[[2013,10,3]]}},"URL":"https:\/\/doi.org\/10.1159\/000351559","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}