{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T15:04:44Z","timestamp":1778857484953,"version":"3.51.4"},"reference-count":23,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmic Res"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background\/Aim:&lt;\/i&gt;&lt;\/b&gt; Corneal epithelial defects may heal slowly in patients with diabetes, limbal stem cell deficiency, extensive chemical burns or anesthetized corneas. Studies have shown that erythropoietin, a glycoprotein hormone that promotes red blood cell proliferation and inhibits apoptosis of erythroid progenitors, may also exert a cytoprotective, antiapoptotic effect on nonhematopoietic cells. The aim of the study was to examine the effect of erythropoietin on the healing process of corneal epithelial erosions in rabbit eyes. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Fifteen New Zealand albino rabbits were divided into 3 groups following induction of unilateral uniform corneal epithelial erosions. The first group received local treatment with erythropoietin-containing cellulose-based gel 4 times daily; the second group received treatment with cellulose-based gel without erythropoietin 4 times daily, and the third group received no treatment. The healing process was monitored twice daily using cobalt-blue-filtered slit lamp photography and digital images of fluorescein-stained corneas until complete re-epithelization was achieved. Following re-epithelization, corneas were removed for histologic processing. One-way analysis of variance and Mann-Whitney tests were used for statistical analysis. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Mean \u00b1 SD time to complete re-epithelization was 55 \u00b1 2.19 h in the group treated with erythropoietin-containing cellulose-based gel, 66.5 \u00b1 14.25 h in the group treated with gel only and 62.2 \u00b1 9.09 h in the untreated group (p = 0.16, not significant). There was no significant difference among the groups in the time to complete re-epithelization or the rate of epithelial healing. Histologic corneal evaluation revealed stromal vascularization in 2 of the 6 erythropoietin-treated rabbits and in neither of the control groups. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Erythropoietin has no beneficial effect on the rate of healing of corneal epithelial erosions in rabbit eyes, and corneal stroma neovascularization seems to be a significant adverse effect.<\/jats:p>","DOI":"10.1159\/000351627","type":"journal-article","created":{"date-parts":[[2017,4,18]],"date-time":"2017-04-18T21:43:13Z","timestamp":1492551793000},"page":"129-133","source":"Crossref","is-referenced-by-count":13,"title":["Effect of Erythropoietin on Healing of Corneal Epithelial Defects in Rabbits"],"prefix":"10.1159","volume":"50","author":[{"given":"Eitan","family":"Livny","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tami","family":"Livnat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maxim","family":"Yakimov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhannad","family":"Masoud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dov","family":"Weinberger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irit","family":"Bahar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2013,8,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097%2FICO.0b013e31812f6d8e"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.2337%2Fdb08-0997"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038%2Feye.1994.42"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.eye.6700616"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097%2F01.ico.0000153102.19776.80"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038%2Feye.2008.379"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1167%2Fiovs.05-1281"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0161-6420%2800%2900289-X"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9440%2810%2963459-1"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00403-005-0615-3"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1096%2Ffj.07-8628com"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-0609.2007.00818.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159%2F000322975"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2141.2008.07014.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1161%2FSTROKEAHA.109.555789"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038%2Fjcbfm.2009.267"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.cdd.4401450"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.0630444100"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.ki.5001546"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1038%2Fjid.2009.219"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa041773"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2009-10-248666"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1097%2F00055735-200108000-00002"}],"container-title":["Ophthalmic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/351627","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/351627","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/351627","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:28:49Z","timestamp":1745432929000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000351627"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":23,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2013,8,1]]},"published-print":{"date-parts":[[2013,8,22]]}},"URL":"https:\/\/doi.org\/10.1159\/000351627","archive":["Portico"],"relation":{},"ISSN":["0030-3747","1423-0259"],"issn-type":[{"value":"0030-3747","type":"print"},{"value":"1423-0259","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}