{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T21:08:17Z","timestamp":1789074497849,"version":"build-2803163510"},"reference-count":38,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Caries Res"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>Tin is a notable anti-erosive agent, and the biopolymer chitosan has also shown demineralisation-inhibiting properties. Therefore, the anti-erosive\/anti-abrasive efficacy of the combination of both compounds was tested under in situ conditions. Twenty-seven volunteers were included in a randomised, double-blind, three-cell crossover in situ trial. Enamel specimens were recessed on the buccal aspects of mandibular appliances, extraorally demineralised (6 \u00d7 2 min\/day) and intraorally treated with toothpaste slurries (2 \u00d7 2 min\/day). Within the slurry treatment time, one-half of the specimens received additional intraoral brushing (5 s, 2.5 N). The tested toothpastes included a placebo toothpaste, an experimental NaF toothpaste (1,400 ppm F&lt;sup&gt;-&lt;\/sup&gt;) and an experimental F\/Sn\/chitosan toothpaste (1,400 ppm F&lt;sup&gt;-&lt;\/sup&gt;, 3,500 ppm Sn&lt;sup&gt;2+&lt;\/sup&gt;, 0.5% chitosan). The percentage reduction of tissue loss (slurry exposure\/slurry exposure + brushing) compared to placebo was 19.0 \u00b1 47.3\/21.3 \u00b1 22.4 after use of NaF and 52.5 \u00b1 30.9\/50.2 \u00b1 34.3 after use of F\/Sn\/chitosan. F\/Sn\/chitosan was significantly more effective than NaF (p \u2264 0.001) and showed good efficacy against erosive and erosive-abrasive tissue loss. This study suggests that the F\/Sn\/chitosan toothpaste could provide good protection for patients who frequently consume acidic foodstuffs.<\/jats:p>","DOI":"10.1159\/000351654","type":"journal-article","created":{"date-parts":[[2013,8,19]],"date-time":"2013-08-19T07:38:39Z","timestamp":1376897919000},"page":"574-581","source":"Crossref","is-referenced-by-count":56,"title":["Randomised in situ Study on the Efficacy of a Tin\/Chitosan Toothpaste on Erosive-Abrasive Enamel 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