{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T02:08:34Z","timestamp":1780106914784,"version":"3.54.0"},"reference-count":16,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroepidemiology"],"published-print":{"date-parts":[[2013]]},"abstract":"<b><i>Background:<\/i><\/b> Essential tremor (ET) is a chronic, progressive neurological disease. Head (neck) tremor may eventually develop in as many as 30-60% of patients, yet it is unclear why. Is its appearance merely a function of advancing disease duration? Alternatively, is patient age a primary factor? The latter would argue for the presence of a biological clock that is important for the expression of this clinical feature of ET. <b><i>Methods:<\/i><\/b> A total of 363 ET patients were enrolled in a cross-sectional, clinical-epidemiological study. Each ET patient underwent a 20-min videotaped neurological examination which included an assessment of the presence\/absence of head tremor. <b><i>Results:<\/i><\/b> Head tremor was present on examination in 140 (38.6%) patients. Young patients, even with longer-duration tremor, rarely had head tremor: 2\/27 (7.4%) patients <40 years old with tremor duration \u226510 years had head tremor versus 121\/283 (42.8%) older patients (>60 years old) with tremor duration \u226510 years (p < 0.001). In a multivariate logistic regression analysis, while head tremor was associated with age (p < 0.001) it was not independently associated with tremor duration (p = 0.26); interestingly, it was associated with gender in that model (p < 0.001). With the exception of 1 patient, head tremor did not begin before the age of 36. <b><i>Conclusions:<\/i><\/b> Data suggest that the appearance of head tremor in ET depends on a biological factor that is intrinsic to the patient (i.e. age) and is not a clear consequence of advancing disease duration.<\/jats:p>","DOI":"10.1159\/000351698","type":"journal-article","created":{"date-parts":[[2013,7,11]],"date-time":"2013-07-11T07:02:39Z","timestamp":1373526159000},"page":"110-115","source":"Crossref","is-referenced-by-count":31,"title":["When Do Essential Tremor Patients Develop Head Tremor Influences of Age and Duration and Evidence of a Biological Clock"],"prefix":"10.1159","volume":"41","author":[{"given":"Elan D.","family":"Louis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2013,7,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10395"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60544-3"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.57.8.1194"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2004.041434"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2008.02296.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000163769.28552.CD"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/mds.1182"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2007.12.001"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2012.03774.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870131303"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8257(200007)15:4<738::AID-MDS1024>3.0.CO;2-4"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20483"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2006.01471.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-0031"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870120620"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1159\/000341903"}],"container-title":["Neuroepidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/351698","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/351698","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:29:28Z","timestamp":1745432968000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000351698"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":16,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2013,8,1]]},"published-print":{"date-parts":[[2013,8,6]]}},"URL":"https:\/\/doi.org\/10.1159\/000351698","archive":["Portico"],"relation":{},"ISSN":["0251-5350","1423-0208"],"issn-type":[{"value":"0251-5350","type":"print"},{"value":"1423-0208","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}