{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T10:02:28Z","timestamp":1760781748678,"version":"3.40.4"},"reference-count":30,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Up to now, the regulation of adrenarche remains a myth although ACTH may possibly play an important role. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Urinary steroid profiling by gas chromatography-mass spectrometry was used to study non-invasively the adrenarchal steroid metabolome in 13 children aged 6-16 years with partial or complete hypopituitarism (HP) whose ACTH\/cortisol axis was affected and compared it with 24 healthy age-matched controls. The sum of DHEA, 16\u03b1-hydroxy-DHEA and 3\u03b2,16\u03b1,17\u03b2-androstenetriol served as markers for adrenarche parameters (AP). The excretion rates of major urinary cortisol metabolites were also determined. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; The excretion rates for AP were significantly lower for the HP subjects than for the controls (p &lt; 0.001). After dividing the HP group into a subgroup treated with hydrocortisone (HC) and an HC-untreated subgroup, a significant difference for AP remained for each subgroup when compared to the control group (p &lt; 0.001 and p = 0.045, respectively). Treatment with HC had no influence on AP. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; The data imply indirectly a significant contribution of ACTH to the regulation of adrenarche. Our results also signify important diagnostic information: absent adrenarche can be indicative of ACTH deficiency.<\/jats:p>","DOI":"10.1159\/000351705","type":"journal-article","created":{"date-parts":[[2013,6,11]],"date-time":"2013-06-11T07:42:17Z","timestamp":1370936537000},"page":"356-360","source":"Crossref","is-referenced-by-count":9,"title":["Absent Adrenarche in Children with Hypopituitarism: A Study Based on Urinary Steroid Metabolomics"],"prefix":"10.1159","volume":"79","author":[{"given":"Claudia","family":"Boettcher","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michaela F.","family":"Hartmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"de Laffolie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus-Peter","family":"Zimmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan A.","family":"Wudy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2013,6,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.9.4536"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1571"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-8165(73)80086-1"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.10.3695"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1210\/en.2002-220456"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1210\/jc.84.9.3382"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2000.01144.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-72-1-23"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-72-1-19"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/ajhb.20528"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1997.1580969.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4731(87)90377-3"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(77)81244-4"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-52-6-1129"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2006.02.005"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2010.10.004"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/0960-0760(93)90132-G"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1159\/000327418"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-33-1-87"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1983.tb09798.x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60010-5"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.02015"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e3181659c14"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2009.27964"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-29-2-273"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00495.2006"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-0710"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-09-0746"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-020969"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1806"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/351705","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/351705","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:29:30Z","timestamp":1745432970000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000351705"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":30,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2013,7,1]]},"published-print":{"date-parts":[[2013,7,16]]}},"URL":"https:\/\/doi.org\/10.1159\/000351705","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"type":"print","value":"1663-2818"},{"type":"electronic","value":"1663-2826"}],"subject":[],"published":{"date-parts":[[2013]]}}}