{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T21:09:06Z","timestamp":1777583346399,"version":"3.51.4"},"reference-count":16,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Nephrol"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background\/Aims:&lt;\/i&gt;&lt;\/b&gt; African-Americans with end-stage renal disease receiving dialysis have more severe secondary hyperparathyroidism than Whites. We aimed to assess racial differences in clinical use of cinacalcet. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; This retrospective cohort study used data from DaVita, Inc., for 45,589 prevalent hemodialysis patients, August 2004, linked to Centers for Medicare &amp;#38; Medicaid Services data, with follow-up through July 2007. Patients with Medicare as primary payer, intravenous vitamin D use, or weighted mean parathyroid hormone (PTH) level &gt;150 pg\/ml at baseline (August 1-October 31, 2004) were included. Cox proportional hazard modeling was used to evaluate race and other demographic and clinical characteristics as predictors of cinacalcet initiation, titration, and discontinuation. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Of 16,897 included patients, 7,674 (45.4%) were African-American and 9,223 (54.6%) were white; 53.2% of cinacalcet users were African-American. Cinacalcet was prescribed for 47.7% of African-Americans and 34.5% of Whites, and for a greater percentage of African-Americans at higher doses at each PTH strata. After covariate adjustment, African-Americans were more likely than Whites to receive cinacalcet prescriptions (hazard ratio 1.17, p &lt; 0.001). The direction and magnitude of this effect appeared to vary by age, baseline PTH, and calcium, and by elemental calcium use. African-Americans were less likely than Whites to have prescriptions discontinued and slightly more likely to undergo uptitration (hazard ratio 1.09, 95% confidence interval 0.995-1.188), but this relationship lacked statistical significance. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Cinacalcet is prescribed more commonly and at higher initial doses for African-Americans than for Whites to manage secondary hyperparathyroidism.<\/jats:p>","DOI":"10.1159\/000353298","type":"journal-article","created":{"date-parts":[[2013,9,11]],"date-time":"2013-09-11T11:55:32Z","timestamp":1378900532000},"page":"104-114","source":"Crossref","is-referenced-by-count":8,"title":["Racial Differences in Clinical Use of Cinacalcet in a Large Population of Hemodialysis Patients"],"prefix":"10.1159","volume":"38","author":[{"given":"Britt B.","family":"Newsome","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan D.","family":"Kilpatrick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiannong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Zaun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig A.","family":"Solid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberly","family":"Nieman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy L.","family":"St. Peter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2013,7,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000014251.87778.01"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2007091002"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.177"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.167.11.1159"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.11.4125"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000034202.91413.EB"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.167"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.05241008"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1592\/phco.29.2.154"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650080912"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111995"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1998.00781.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038\/nm1295-1309"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2008.03.020"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfn592"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2008080853"}],"container-title":["American Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/353298","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/353298","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:35:02Z","timestamp":1745433302000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000353298"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":16,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2013,8,1]]},"published-print":{"date-parts":[[2013,8,23]]}},"URL":"https:\/\/doi.org\/10.1159\/000353298","archive":["Portico"],"relation":{},"ISSN":["0250-8095","1421-9670"],"issn-type":[{"value":"0250-8095","type":"print"},{"value":"1421-9670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}