{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:36:51Z","timestamp":1770824211392,"version":"3.50.1"},"reference-count":20,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestion"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background\/Aims:&lt;\/i&gt;&lt;\/b&gt; In Japan, a systematic eradication strategy for &lt;i&gt;Helicobacter pylori&lt;\/i&gt; has been constructed, and consists of a proton pump inhibitor\/amoxicillin and clarithromycin (PPI\/AC) therapy as the first-line regimen and proton pump inhibitor\/amoxicillin and metronidazole (PPI\/AM) therapy as the second-line regimen. The cumulative rate of &lt;i&gt;H. pylori&lt;\/i&gt; eradication has not been reported. Therefore, we investigated the annual and cumulative eradication rate to verify the efficacy of the \u2018Japanese eradication strategy'. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Patients who received first-line PPI\/AC therapy and, if necessary, second-line PPI\/AM therapy between 2000 and 2009 were retrospectively analyzed. The annual cumulative eradication rate was calculated. Data were subjected to intention-to-treat analysis. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; PPI\/AC was administered to 1973 patients (male n = 1,162, female n = 811; mean age: 55.8 years, range: 15-87), and 250 patients received PPI\/AM. The eradication rate for the PPI\/AC regimen was 65.3%, and it gradually but significantly decreased over 10 years (p &lt; 0.05). For the PPI\/AM regimen, the eradication rate was 84.0%, with no change in the annual eradication rate. The cumulative eradication rates were 76.0% in intention-to-treat analysis and 98.4% in per-protocol analysis, respectively, which provided a consistent annual eradication rate without decreases in effectiveness. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Although the eradication rate for the first-line PPI\/AC regimen decreased over time, the \u2018Japanese eradication strategy' provided a sufficient eradication rate.<\/jats:p>","DOI":"10.1159\/000353313","type":"journal-article","created":{"date-parts":[[2013,12,12]],"date-time":"2013-12-12T08:18:58Z","timestamp":1386836338000},"page":"272-278","source":"Crossref","is-referenced-by-count":19,"title":["Ten-Year Trend of the Cumulative Helicobacter pylori Eradication Rate for the \u2018Japanese Eradication Strategy'"],"prefix":"10.1159","volume":"88","author":[{"given":"Hitoshi","family":"Sasaki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihito","family":"Nagahara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariko","family":"Hojo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Asaoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenshi","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taro","family":"Osada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumio","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2013,12,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2009.00738.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01393.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3164\/jcbn.10-10"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2011.00922.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04887.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.091272"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2009.00714.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00740-07"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01541.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2012.05.010"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e31802cbc1a"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01401.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2007.00518.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2008.87"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-5378.2000.00013.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2001.00929.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1999.00526.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1358\/mf.2003.25.2.723687"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2001.00980.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2007.00555.x"}],"container-title":["Digestion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/353313","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/353313","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/353313","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:35:12Z","timestamp":1745433312000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000353313"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":20,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2013,12,1]]},"published-print":{"date-parts":[[2013,12,24]]}},"URL":"https:\/\/doi.org\/10.1159\/000353313","archive":["Portico"],"relation":{},"ISSN":["0012-2823","1421-9867"],"issn-type":[{"value":"0012-2823","type":"print"},{"value":"1421-9867","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}