{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:51:42Z","timestamp":1787017902145,"version":"build-2736575974"},"reference-count":14,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2013]]},"abstract":"<b><i>Background:<\/i><\/b> Pulmonary interstitial emphysema (PIE) is a common respiratory illness in preterm infants associated with significant morbidity and mortality for which the ventilatory management is imperfect. <b><i>Objectives:<\/i><\/b> To evaluate the impact of high-frequency oscillatory ventilation (HFOV) with a low oscillatory frequency and thus prolonged expiratory time in preterm infants with severe PIE. <b><i>Methods:<\/i><\/b> In a retrospective cohort study, preterm infants \u226430 weeks' gestation with radiological findings of severe PIE, and either high FiO<sub>2<\/sub> or persistent respiratory acidosis were studied if managed on HFOV with a low frequency (5-6 Hz, inspiratory time 30%) for >24 h. Trends in physiological and ventilatory parameters were examined over the first 72 h, radiological changes noted, and in-hospital outcomes ascertained. <b><i>Results:<\/i><\/b> 19 cases were identified and analysed in two groups: 14 with bilateral and 5 with predominantly unilateral disease. After transition to low-frequency HFOV, physiological responses were seen in both groups, in particular a rapid and sustained improvement in oxygenation in the bilateral group (mean (SD) alveolar-arterial oxygen difference at baseline: 404 \u00b1 206 mm Hg; 4 h post-transition: 262 \u00b1 181 mm Hg; 72 h: 155 \u00b1 74 mm Hg; p = 0.0003). This occurred following a reduction in mean airway pressure (mean (SD) baseline: 14 \u00b1 3.9 cm H<sub>2<\/sub>O; 72 h: 12 \u00b1 2.9 cm H<sub>2<\/sub>O; p = 0.011). In the unilateral group, radiological resolution of PIE was observed on re-inflation following collapse of the affected lung. Overall, 15 infants survived, including 10 of the bilateral cases (71%), and all of the unilateral cases. <b><i>Conclusion:<\/i><\/b> HFOV with a low oscillatory frequency may afford benefit in preterm babies with severe PIE.<\/jats:p>","DOI":"10.1159\/000353376","type":"journal-article","created":{"date-parts":[[2013,9,24]],"date-time":"2013-09-24T07:19:22Z","timestamp":1380007162000},"page":"243-249","source":"Crossref","is-referenced-by-count":26,"title":["High-Frequency Oscillatory Ventilation with Low Oscillatory Frequency in Pulmonary Interstitial Emphysema"],"prefix":"10.1159","volume":"104","author":[{"given":"Katharine A.G.","family":"Squires","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio G.","family":"De Paoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A.","family":"Dargaville","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2013,9,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)80964-3"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(79)80444-8"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211456"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-999947"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1263298"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2006.02044.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-993880"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1542\/peds.100.4.593"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/965159"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(79)80598-3"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/PL00007624"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)81046-7"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(83)80483-1"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(80)80443-4"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/353376","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/353376","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T14:35:55Z","timestamp":1745418955000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000353376"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":14,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2013,11,1]]},"published-print":{"date-parts":[[2013,11,12]]}},"URL":"https:\/\/doi.org\/10.1159\/000353376","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.5125336","asserted-by":"subject"}]},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}