{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T05:19:40Z","timestamp":1789017580090,"version":"build-2803163510"},"reference-count":37,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemotherapy"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>Background: Chemotherapy with L-asparaginase is associated with hepatotoxicity resulting in organ dysfunction in patients with preexisting liver disorders. This study investigated the protective effect of L-carnitine during chemotherapy in a steatotic rat liver model. Methods: Livers from nonsteatotic and steatotic rats were tested in an isolated liver reperfusion model adding L-asparaginase and L-carnitine to the reperfusate. Portal venous pressure (PVP), hepatic oxygen consumption, aspartate aminotransferase, lactate dehydrogenase, glutamate dehydrogenase and \u03b1-glutathione S-transferase levels were assessed. Further histopathological analysis was performed and cytotoxicity was verified in vitro. Results:L-Asparaginase induced toxicity in fatty livers whereas low toxicity was observed in normal livers. L-Carnitine induced a decline in PVP and oxygen consumption, and reduced parenchymal and mitochondrial damage in fatty livers. Cytotoxicity of L-asparaginase was not impaired by the presence of L-carnitine. Conclusions: Our study emphasizes the potential of L-carnitine to reduce L-asparaginase-induced hepatotoxicity in patients with preexisting liver disorders.<\/jats:p>","DOI":"10.1159\/000353402","type":"journal-article","created":{"date-parts":[[2013,10,31]],"date-time":"2013-10-31T07:41:55Z","timestamp":1383205315000},"page":"167-175","source":"Crossref","is-referenced-by-count":25,"title":["L-Carnitine Ameliorates L-Asparaginase-Induced Acute Liver Toxicity in Steatotic Rat Livers"],"prefix":"10.1159","volume":"59","author":[{"given":"Anne","family":"Roesmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamdouh","family":"Afify","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Panse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albrecht","family":"Eisert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Steitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rene H.","family":"Tolba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2013,10,31]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25489"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20107"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200544040-00003"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2006.07.009"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S1040-8428(98)00015-8"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.03.011"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018824004318"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199709000-00021"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/0959-8049(92)90513-2"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159\/000095827"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.2950230208"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197108)28:2<361::AID-CNCR2820280215>3.0.CO;2-3"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-42647"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pa.27.040187.001353"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.719"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20636"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31818e04d1"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1159\/000240020"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.4161\/oxim.3.6.14416"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000093832.15249.AD"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(97)80256-5"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2000.tb02102.x"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.1997.tb00450.x"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.22.3000"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1084\/jem.118.1.99"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4274(86)90113-X"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-7843.2006.00024.x"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mn.7800206"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1186\/1423-0127-19-32"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2007.04714.x"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1159\/000323621"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0442.2007.00897.x"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1159\/000321296"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(92)90158-Q"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006891208220"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1007\/BF00978367"}],"container-title":["Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/353402","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/che\/article-pdf\/59\/3\/167\/3925784\/000353402.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/che\/article-pdf\/59\/3\/167\/3925784\/000353402.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:36:07Z","timestamp":1745433367000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000353402"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":37,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2014,1,1]]},"published-print":{"date-parts":[[2014,1,9]]}},"URL":"https:\/\/doi.org\/10.1159\/000353402","archive":["Portico"],"relation":{},"ISSN":["0009-3157","1421-9794"],"issn-type":[{"value":"0009-3157","type":"print"},{"value":"1421-9794","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}