{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T21:22:58Z","timestamp":1788384178111,"version":"build-2803163510"},"reference-count":28,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2013]]},"abstract":"<b><i>Background:<\/i><\/b> Disseminated granuloma annulare (DGA) is a benign and usually asymptomatic skin disease. However, many patients feel aesthetically disfigured and ask for treatment. Until today, no standard therapy is recommended. <b><i>Objective:<\/i><\/b> To evaluate the safety and efficacy of oral vitamin E treatment compared to the natural course of DGA. <b><i>Methods:<\/i><\/b> This single-centre observational cohort study included 38 consecutive patients with histologically confirmed DGA. 21 patients underwent treatment with oral vitamin E, whereas 17 patients preferred a wait-and-see approach. <b><i>Results:<\/i><\/b> Complete healing (40%) and improvement (30%) were frequently seen under oral vitamin E therapy. However, DGA also spontaneously disappeared in 31% and improved in 25% of untreated control patients. Vitamin E therapy was very well tolerated. <b><i>Conclusions:<\/i><\/b> Oral vitamin E treatment is a safe and probably effective therapy for DGA. As the natural course of DGA leads to complete healing or significant improvement in many cases, \u2018primum nil nocere' should be the maxim.<\/jats:p>","DOI":"10.1159\/000353528","type":"journal-article","created":{"date-parts":[[2013,8,29]],"date-time":"2013-08-29T07:25:09Z","timestamp":1377761109000},"page":"83-88","source":"Crossref","is-referenced-by-count":14,"title":["Treatment of Disseminated Granuloma Annulare with Oral Vitamin E: \u2018Primum Nil Nocere'"],"prefix":"10.1159","volume":"227","author":[{"given":"Heiko","family":"Poppe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidia M.","family":"Poppe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Goebeler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Trautmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2013,8,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-005-1047-x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(89)70005-0"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.05947.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06594.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.2174\/1871530311006040348"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.2010.10719848"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.19.4.1125"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.04590.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159\/000247580"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159\/000246297"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1046\/j.0007-0963.2001.04527.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159\/000083514"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1186\/1471-5945-2-5"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0647"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.09923.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.annder.2012.11.004"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2005.02229.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06371.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.2165\/11311040-000000000-00000"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.142.3.394"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.142.9.1236"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.075663"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.91847"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.02.022"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.2011.00574.x"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1007\/s001050050901"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.2005.00145.x"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-011-2185-y"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/353528","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/353528","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:37:08Z","timestamp":1745433428000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000353528"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":28,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2013,10,1]]},"published-print":{"date-parts":[[2013,10,3]]}},"URL":"https:\/\/doi.org\/10.1159\/000353528","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}