{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T23:57:38Z","timestamp":1790207858753,"version":"4.1.0"},"reference-count":54,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Photodynamic therapy (PDT) with Metvix\u00ae is a good therapeutic option to treat actinic keratosis, but it presents drawbacks (pain, lesion recurrences, heterogeneous outcome), emphasizing the possible need to individualize treatment. &lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; We assessed whether PDT clinical outcome and pain during treatment were correlated with protoporphyrin IX fluorescence intensity and photobleaching. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; 25 patients were treated by Metvix PDT. The outcome was evaluated after 1.3 (\u00b10.4), 7.6 (\u00b11.8), 13.2 (\u00b11.2) and 33.6 (\u00b13.0) months. After administration of Metvix, red light (632 \u00b1 10 nm) was delivered with a light-emitting diode panel device. The outcome was assessed on a cosmetoclinical scale. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; All patients who showed a fluorescence level before PDT treatment above a certain threshold had a complete recovery at 33.6 (\u00b13.0) months. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Our approach could be used to individualize PDT treatment based on the pretreatment fluorescence level, and to predict its long-term outcome.<\/jats:p>","DOI":"10.1159\/000353775","type":"journal-article","created":{"date-parts":[[2013,10,15]],"date-time":"2013-10-15T07:49:12Z","timestamp":1381823352000},"page":"214-225","source":"Crossref","is-referenced-by-count":34,"title":["Correlation between Protoporphyrin IX Fluorescence Intensity, Photobleaching, Pain and Clinical Outcome of Actinic Keratosis Treated by Photodynamic 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