{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:34:56Z","timestamp":1745469296786,"version":"3.40.4"},"reference-count":30,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiology"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objectives:&lt;\/i&gt;&lt;\/b&gt; \u03b1-Lipoic acid (ALA) is widely used for diabetic neuropathy due to its antioxidant properties. We evaluated its potential for preventing contrast-induced nephropathy (CIN). &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; We conducted a prospective randomized controlled trial to evaluate the efficacy of ALA in CIN prevention. Two hundred and two patients with basal renal insufficiency who received elective coronary angiography were randomized to the ALA group [ALA treatment for 2 days (600 mg orally three times a day before and after coronary catheterization, n = 100)] or the control group (n = 102). The primary end point was the maximum increase in serum creatinine (sCr) and the secondary end point was the incidence of CIN defined as an increase in sCr of either \u226525% or \u226544.2 \u00b5mol\/l. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Mean maximum increase in sCr was not different between the ALA and the control group (-1.32 \u00b1 30.5 vs. -1.19 \u00b1 30.1 \u00b5mol\/l, respectively; p = 0.977). sCr did not significantly change from baseline (120.8 \u00b1 69.8 vs. 122 \u00b1 88.1 \u00b5mol\/l) in the ALA group and the simple saline hydration group (108.2 \u00b1 37.5 vs. 110 \u00b1 49 \u00b5mol\/l). There was a lower rate of CIN in the ALA group than in the control group, but the difference was not statistically significant (3.0 vs. 6.9%, respectively; p = 0.332). &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; ALA showed no benefit in CIN prevention.<\/jats:p>","DOI":"10.1159\/000353812","type":"journal-article","created":{"date-parts":[[2013,8,29]],"date-time":"2013-08-29T07:25:08Z","timestamp":1377761108000},"page":"159-166","source":"Crossref","is-referenced-by-count":7,"title":["Alpha-Lipoic Acid for the Prevention of Contrast-Induced Nephropathy in Patients Undergoing Coronary Angiography: The ALIVE Study - A Prospective Randomized 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