{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T09:17:05Z","timestamp":1761988625350,"version":"3.40.4"},"reference-count":12,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cytologica"],"published-print":{"date-parts":[[2013]]},"abstract":"<b><i>Objective:<\/i><\/b> A number of cervical smears may exhibit unequivocal low-grade squamous intraepithelial lesions (LSIL) in association with atypical cells cytomorphologically suspicious, but not sufficient to be interpreted as high-grade squamous intraepithelial lesions (HSIL). These lesions are presently called LSIL, atypical squamous cells cannot exclude HSIL (LSIL\/ASC-H). Previous studies have shown that LSIL\/ASC-H and ASC-H are both equivocal for HSIL and have a high risk of underlying HSIL. However, in researching the literature only two studies were found which rendered the results as cervical intraepithelial neoplasia (CIN) 2 and CIN3 separately. The purpose of this study was to compare the distribution of biopsy results for CIN2 and CIN3 in patients with ASC-H, HSIL, and LSIL\/ASC-H. <b><i>Study Design:<\/i><\/b> Between January 2005 and December 2011, cervicovaginal smears (98,594) with a diagnosis of ASC-H, LSIL, LSIL\/ASC-H, or HSIL were re-evaluated to determine the prevalence of future lesion development. <b><i>Results:<\/i><\/b> A total of 252 patients who had histologic follow-up within a year were selected. Among these, LSIL\/ASC-H (31.7%) had the highest prevalence of CIN2 between LSIL (9.3%), ASC-H (10%), and HSIL (16%). All differences were statistically significant. <b><i>Conclusion:<\/i><\/b> Because of the high predictive value of CIN2, LSIL\/ASC-H may have further importance, especially in women of different age groups.<\/jats:p>","DOI":"10.1159\/000353824","type":"journal-article","created":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T12:37:37Z","timestamp":1380631057000},"page":"581-584","source":"Crossref","is-referenced-by-count":6,"title":["Is the Low-Grade Squamous Intraepithelial Lesion\/Atypical Squamous Cells Cannot Exclude High-Grade Squamous Intraepithelial Lesion Category Associated with Cervical Intraepithelial Neoplasia 2?"],"prefix":"10.1159","volume":"57","author":[{"given":"Handan","family":"\u00c7etiner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00f6zde","family":"K\u0131r","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ecmel","family":"Kaygusuz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye\u015fim","family":"Sa\u011fl\u0131can","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Canan","family":"Kabaca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2013,10,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1309\/QRDNMWWAKJQTVJGF"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.5146\/tjpath.2010.01045"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.2008.00561.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1186\/1742-6413-4-7"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/dc.21194"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22169"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159\/000338212"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.20004"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.16.2114"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11721"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-0489-8_5"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.06.069"}],"container-title":["Acta Cytologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/353824","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/353824","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:39:39Z","timestamp":1745433579000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000353824"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":12,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2013,12,1]]},"published-print":{"date-parts":[[2013,11,29]]}},"URL":"https:\/\/doi.org\/10.1159\/000353824","archive":["Portico"],"relation":{},"ISSN":["0001-5547","1938-2650"],"issn-type":[{"type":"print","value":"0001-5547"},{"type":"electronic","value":"1938-2650"}],"subject":[],"published":{"date-parts":[[2013]]}}}