{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T22:12:31Z","timestamp":1773871951996,"version":"3.50.1"},"reference-count":14,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Perfusion index (PI) could reflect peripheral flow. Preterm infants with hemodynamically significant patent ductus arteriosus (hsPDA) will have left-to-right shunt across PDA causing less blood flow to the lower legs. &lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; To evaluate pre- and postductal PI differences (&amp;#x0394;PI) in hsPDA. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Preterm infants with gestational age &lt;34 weeks were assessed for &amp;#x0394;PI on days 1, 3, and 7 of life with simultaneous echocardiography. Based on echocardiography, each infant was categorized into hsPDA, non-hsPDA, and no PDA. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Thirty infants (16 males), median age 31 weeks (interquartile range, IQR, 29-32) and weight 1,490 g (IQR 1,100-1,670) were enrolled. On days 1 and 3 of life, the &amp;#x0394;PI of infants with hsPDA (1.57%, IQR 0.28-2.32, n = 14, and 1.32%, IQR 0.28-1.83, n = 10) were significantly higher than those without hsPDA (0.14%, IQR -0.03 to 0.30, n = 16, and 0.08%, IQR -0.07 to 0.26, n = 20), p = 0.009 and 0.005, respectively. At all time points (days 1, 3, and 7 of life, n = 84), &amp;#x0394;PI &gt;1.05% had sensitivity, specificity, positive predictive value, and negative predictive value of 66.7, 100, 100, and 86.4%, respectively, to detect hsPDA. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; The pre- and postductal PI differences were significantly related to the hemodynamic changes of PDA and might be useful to detect hemodynamically significant PDA.<\/jats:p>","DOI":"10.1159\/000353862","type":"journal-article","created":{"date-parts":[[2013,9,24]],"date-time":"2013-09-24T11:19:22Z","timestamp":1380021562000},"page":"250-254","source":"Crossref","is-referenced-by-count":21,"title":["Perfusion Index as a Diagnostic Tool for Patent Ductus Arteriosus in Preterm Infants"],"prefix":"10.1159","volume":"104","author":[{"given":"Anant","family":"Khositseth","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natthachai","family":"Muangyod","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pracha","family":"Nuntnarumit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2013,9,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.2223\/JPED.1419"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-008-0059-9"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-009-0983-3"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211465"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(95)70172-9"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1136\/adc.62.9.957"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/01.PCC.0000201002.50708.62"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1186\/1824-7288-36-6"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2007.00439.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1542\/neo.5-3-e86"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159\/000092870"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2001.tb00282.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2011.02304.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2008.185"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/353862","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/353862","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:39:45Z","timestamp":1745433585000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000353862"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":14,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2013,11,1]]},"published-print":{"date-parts":[[2013,11,12]]}},"URL":"https:\/\/doi.org\/10.1159\/000353862","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}