{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T02:01:10Z","timestamp":1793325670496,"version":"4.5.0"},"reference-count":28,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Nephrol"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Recent reports suggest that low birthweight (LBW) is a risk factor for kidney diseases, including focal segmental glomerulosclerosis (FSGS), although the underlying pathological mechanism remains unknown. Podocyte loss triggers glomerulosclerosis; however, whether FSGS in LBW children is associated with podocytopenia is unclear. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; We reviewed the birthweights and gestational age of all patients who underwent renal biopsies from 1995 to 2011 at our Institute. Sixteen patients had FSGS, of which 6 (37.5%) had LBW; this LBW rate was significantly higher than the overall LBW rate in Japan (9.7%). The incidence of LBW was also high in patients with minimal change nephrotic syndrome (MCNS; 12.5%). The glomerular cell numbers in biopsy sections were calculated using computer image analysis and compared with FSGS of normal birthweight (NBW-FSGS). Biopsy specimens from age-matched patients with MCNS were also compared. Wilms' tumor-1 (WT1) immunohistochemistry was performed to enumerate the podocytes. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; All patients in the LBW-FSGS group were also preterm, with an average gestational age of 25.8 weeks. The number of podocytes per glomerulus in the LBW-FSGS patients was 34 and 24% lower as compared to that in the MCNS patients (p &lt; 0.01) and the NBW-FSGS patients (p &lt; 0.05), respectively. Similar results were observed for the WT1-positive glomerular cell number. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; LBW and premature birth were associated with FSGS development. The possibility that LBW and premature birth may be predisposing factors for severe podocytopenia in children with FSGS warrants further investigation.<\/jats:p>","DOI":"10.1159\/000353898","type":"journal-article","created":{"date-parts":[[2013,8,6]],"date-time":"2013-08-06T08:47:21Z","timestamp":1375778841000},"page":"149-157","source":"Crossref","is-referenced-by-count":67,"title":["Low Birthweight and Premature Birth Are Risk Factors for Podocytopenia and Focal Segmental Glomerulosclerosis"],"prefix":"10.1159","volume":"38","author":[{"given":"Yohei","family":"Ikezumi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiaki","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamaki","family":"Karasawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroya","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Nishimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Uchiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2013,8,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2007.01809.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2008.886"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.acvd.2011.10.006"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2008.12.042"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.09712.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-011-1843-8"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.01700408"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2004080720"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1994.17"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005010055"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1106556"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2003.10.024"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2007020252"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00787.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfm829"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(05)80005-8"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1998.00121.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-3226"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2005.00294.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-011-2083-7"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-007-0516-0"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00710805"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1053\/snep.2003.50025"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-006-0027-4"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-009-1407-3"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.00225.x"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1992.tb13726.x"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1998.00044.x"}],"container-title":["American Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/353898","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/353898","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:40:15Z","timestamp":1745433615000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000353898"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":28,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2013,8,1]]},"published-print":{"date-parts":[[2013,8,23]]}},"URL":"https:\/\/doi.org\/10.1159\/000353898","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.5125414","asserted-by":"subject"}]},"ISSN":["0250-8095","1421-9670"],"issn-type":[{"value":"0250-8095","type":"print"},{"value":"1421-9670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}