{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T22:10:46Z","timestamp":1762639846636,"version":"3.40.4"},"reference-count":24,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>Radiodermatitis is a very common side effect in cancer treatment often leading to therapy delays and diminution of the patients' health state and quality of life. Despite a wide range of supportive strategies, radiodermatitis is still a major problem necessitating further improvements in prevention and treatment. Lactokine is a milk-based protein shown to assist in the reduction of skin redness. The treatment is a unique FDA-approved skin care system (R1 and R2). In this case presentation we describe the prophylactic use of R1 and R2 in a 63-year-old, female patient with a squamous cell carcinoma of the hypopharynx undergoing a platin-based chemoradiation. The application was feasible and safe and the patient developed only a slight radiodermatitis. To our knowledge this is the first report in the literature on the prophylactic use of R1 and R2. Further evidence will be provided by a prospective, clinical trial we have launched (CREAM-1; study registration in ISRCTN Registry: ISRCTN87302591). We also review the literature to give an overview about common strategies in the management of radiodermatitis.<\/jats:p>","DOI":"10.1159\/000353974","type":"journal-article","created":{"date-parts":[[2013,9,26]],"date-time":"2013-09-26T14:06:23Z","timestamp":1380204383000},"page":"171-174","source":"Crossref","is-referenced-by-count":22,"title":["Prophylaxis of Acute Radiation Dermatitis with an Innovative FDA-Approved Two-Step Skin Care System in a Patient with Head and Neck Cancer Undergoing a Platin-Based Radiochemotherapy: A Case Report and Review of the Literature"],"prefix":"10.1159","volume":"227","author":[{"given":"M.F.","family":"H\u00e4fner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Fetzner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.C.","family":"Hassel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Debus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Potthoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2013,9,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(02)02756-6"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(99)00558-1"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(94)00423-I"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097\/01.SMJ.0000140866.97278.87"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr139"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-011-1324-4"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(99)00146-2"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S0936-6555(05)80971-9"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(00)00322-4"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1754-9485.2010.02170.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2005.04.013"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/00002820-200212000-00007"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.07.063"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3109\/02841869609100721"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(01)00327-9"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.04751.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(96)01882-8"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-010-0465-0"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s00066-011-2204-z"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(00)00782-3"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1673.1997.tb00672.x"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1097\/01.NCC.0000305680.06143.39"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/S0936-6555(98)80064-2"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2010.01801.x"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/353974","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/353974","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:40:53Z","timestamp":1745433653000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000353974"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":24,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2013,11,1]]},"published-print":{"date-parts":[[2013,11,12]]}},"URL":"https:\/\/doi.org\/10.1159\/000353974","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"type":"print","value":"1018-8665"},{"type":"electronic","value":"1421-9832"}],"subject":[],"published":{"date-parts":[[2013]]}}}